ID A0A0N4XZC2_NIPBR Unreviewed; 1620 AA.
AC A0A0N4XZC2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=EF-hand domain-containing protein {ECO:0000313|WBParaSite:NBR_0000851301-mRNA-1};
GN ORFNames=NBR_LOCUS8514 {ECO:0000313|EMBL:VDL72103.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000851301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000851301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL72103.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; UYSL01020016; VDL72103.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4XZC2; -.
DR WBParaSite; NBR_0000851301-mRNA-1; NBR_0000851301-mRNA-1; NBR_0000851301.
DR OMA; DPNKECA; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1244..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1279..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1324..1353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1429..1452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1468..1503
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 476..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..527
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..849
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 380
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 748
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1620 AA; 184978 MW; DEF1815804A77CAB CRC64;
MYGLAAEEAR REQKTESGPF AVRKSTLASN APVKEKGPSS LFIFSEDNFI RRNAKAIIEW
GPFEYFILLT IIGNCVVLAM EQHLPKNDKK PLSELLERTE PYFMGIFCLE CVLKIIAFGF
IAHKGSYLRS GWNIMDFIVV VSGFAFHRLI VSVFSVVTML PVSPAAAGGH SGQVETVDLR
TLRAVRVLRP LKLVSGIPSD RLKNKAERAS FRWWFCARAH EAQARACAAA AAHKTPTIFS
RESSEQGTSR LARQAADANY QGYPWKDGLQ VVLKSILCAM APLLQIGLLV LFAIVIFAII
GLEFYSGAFH SACYNDRGEI ENVSEKPSPC TNKTTTMGVY NCDVEGTTCL NKWIGPNYGI
TSFDNIAFAM ITVFQCITME GWTTVMYYTN DSLGSTYNWA YFIPLIVLGS FFMLNLVLGV
LSGEFAKERE RVENRREFLK LRRQQQIERE LNGYLEWIMA AEEVILKEDR TTEEEKQAIL
DGRRRAETKK KMKDASKQQS TETEEDMEEE EEELDEEYLD EGGEPGEDFE DNKLSNHNLE
RRRRGCYYAI CKRIRKARIQ MRVIVKTQIF YWSVITLVFL NTACVASEHY GQPPWLTKFL
QYAEYVFLGI FIMEVLLKLF AMGSRTYFAS KFNRFDCIVI VGSAFEVIWA EVKGGSFGIS
VLRALRLLRI FKLTSYWVSL RNLVRSLMNS MRSIISLLFL LFLFILIFAL LGMQLFGGKF
NFPTMHPYTH FDTFPVALIT VFQILTGEDW NEVMYLAIEA QGGIYGGGMV YCIYFIVLVL
FGNYTLLNVF LAIAVDNLAN AQELTAAEEA DEKANEMDDS EEEESDGDHC AIDMDGNDQD
DDEECEEEES PFGGPRPMVP YTSMFFLSPS NPLRVLVHSI VCTKYFEMMV MGVICLSSIS
LAAEDPVDEE NPRNKVLQYM DYCFTGVFAC EMLLKLIDQG IILHPGSYCR DFWNILDGVV
VTCALVAFGF AGTEGSAGKN LNTIKSLRVL RVLRPLKTIK RIPKLKAVFD CVVNSLKNVF
NILIVYFLFQ FIFGVIAVQL FNGKFFYCTD KTKRFAHQCH GQFFIFDNQN EPPRVEQREW
RLRPFNYDNT INAMLTLFVV TTGEGWPGIR QNSMDTTFED QGPSPFYRVE VALFYVMFFI
VFPFFFVNIF VALIIITFQE QGEAELSEGD LDKNQKQCID FALNARPRSL FMPEDKNSIK
YRIWRLVTSA PFEYFIMAMI CCNTIILMMK FHGNSDFYEK VLRLFNTALT AVFTVESILK
ILAFGVRNYF RDGWNRFDFV TVVGSITDAL VTEFGGHFVS LGFLRLFRAA RLIRLLQQGY
TIRILLWTFV QSFKALPYVC LLIGMLFFIY AIVGMQVFGN IWLNAATEIN RHNNFQSFFN
SVILLFRCAT GEGWQDIMMA CGAQKDCARA GSDEINYDKG QTCGSNVSYA YFTSFVFLSS
FLMLNLFVAV IMDNFDYLTR DSSILGPHHL DEFIRVWADY DPAATGRIHY TDMYDMLRNI
TPPVGFGRKC PYRLAYKHLV RMNMPVAEDG TVHFTTTLFA LIRESLSIKM RPVEEMDEAD
EELRQTLKKI WPLKAKKNMI DLVVPPNHEL CFQKLTVGKI YAGLLILENY RAKKSGTEVG
//
