ID A0A0N4Y0H0_NIPBR Unreviewed; 440 AA.
AC A0A0N4Y0H0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN ORFNames=NBR_LOCUS9021 {ECO:0000313|EMBL:VDL72610.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000902001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000902001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL72610.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001831};
CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC {ECO:0000256|ARBA:ARBA00009632}.
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DR EMBL; UYSL01020078; VDL72610.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4Y0H0; -.
DR WBParaSite; NBR_0000902001-mRNA-1; NBR_0000902001-mRNA-1; NBR_0000902001.
DR OMA; QGHADYT; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR InterPro; IPR026888; AcetylCoA_hyd_C.
DR InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR InterPro; IPR046433; ActCoA_hydro.
DR InterPro; IPR003702; ActCoA_hydro_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR21432:SF13; ACETYL-COA HYDROLASE; 1.
DR PANTHER; PTHR21432; ACETYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR Pfam; PF02550; AcetylCoA_hydro; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 76..182
FT /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02550"
FT DOMAIN 276..430
FT /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13336"
SQ SEQUENCE 440 AA; 48117 MW; 72E9DA15FAD30A6D CRC64;
MRWSLTLQRN FLPLASQLSI PVLGSHIYVH AHSSTPTELL DALCRRVDSH GLTDLRPIHI
LLGGKVPWAD KKYHGKIRSN GLFLCSTVRA LVKQGHADYT PVFLSDMPSY FYNKTFPVDV
ALISISISDE QGFCTLGCNV DTSKAAIEVA TKVIAVVNPN MPRTYGNSMI HQSRIDCFVE
TDRELYAKPE GMNASEEEVK IGRLIADNLV DNESTLQLGI GAIPDATLLA MKNHKNLGIH
TELLGDGVID LVESGVINNS KKTVMPGKIT TCFAFGTKRF YRFLHNNPMI HFDCCSWTNH
SDTIRANSKM VCINSGIEID ITGQIASDSI GSIFYSGFGG QTDFMTAAAT CYDGLGKAII
AFPSRTAKGQ SKIVVTLAEG AGVVTTRGHT RYVVTEYGIA SLGGKNVRQR AYELIKIAHP
DDRAGLERAA FERLKCMPSP
//
