ID A0A0N4Y1S0_NIPBR Unreviewed; 436 AA.
AC A0A0N4Y1S0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Axin-like protein 1 (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:NBR_0000958801-mRNA-1};
GN ORFNames=NBR_LOCUS9589 {ECO:0000313|EMBL:VDL73178.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000958801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000958801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL73178.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYSL01020163; VDL73178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4Y1S0; -.
DR STRING; 27835.A0A0N4Y1S0; -.
DR WBParaSite; NBR_0000958801-mRNA-1; NBR_0000958801-mRNA-1; NBR_0000958801.
DR OMA; HMAMSTQ; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF2; AXIN; 1.
DR Pfam; PF00778; DIX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 11..120
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 349..433
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 160..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 49002 MW; CBD1722FEC8DE97C CRC64;
MALDACNFSS SVDAVLHDAH ALQAFREWIR LDPSRPSDCL ALHFAIKGYQ TYLSRKEPNT
SSMACTLHRK FISQRTGSCS FLPSAIRKEM STRVHSLNSQ QPPYPELFDP VLPALRKQLN
ALHSQFVASH SFMAFLARNS SEGSSNSTPL DELPPYPYLG PTSTLAREPA RKGRGSKTRA
YSYDASTSRH NNDSSRSIAI DRERNLFKHS DGSIRHDLPE ARQAFVGVLT ERLDVIRKEL
ERCNENTYAR DLPRDLAACS LLPSLHDNRI LEETTSDEEV EKSMDYRFSD SSGFCSSESA
YLSDRSFGKK KIGFDFTPNH LGMISSPRRS NNPVPSQSIF CTMQCPPFPS SPLTLMLREA
GQPPMVAKIP NEMITLAKFR RTFGISRTEN MRFLFKSTCE DGSAPFQWSL ITDDEAILPL
FDGKISAECR RLTDSD
//
