ID A0A0N4Y4C5_NIPBR Unreviewed; 378 AA.
AC A0A0N4Y4C5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=phosphatidylinositol N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012420};
DE EC=2.4.1.198 {ECO:0000256|ARBA:ARBA00012420};
DE AltName: Full=GlcNAc-PI synthesis protein {ECO:0000256|ARBA:ARBA00032160};
GN ORFNames=NBR_LOCUS10740 {ECO:0000313|EMBL:VDL74329.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001073901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001073901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL74329.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
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DR EMBL; UYSL01020377; VDL74329.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4Y4C5; -.
DR WBParaSite; NBR_0001073901-mRNA-1; NBR_0001073901-mRNA-1; NBR_0001073901.
DR OMA; QCVLPTM; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IEA:InterPro.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..139
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 198..350
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 378 AA; 42801 MW; 267F9F490E898009 CRC64;
MKDSVEEKKF YNIALVSDFF CPNAGGVETH IYFLAQCLLE LGHKVVVITH AYGKRRGIRY
LSNGLKVYYL PFLVVYNGCS LATIIGSLPW LRKIFLREKI DLIHGHSTFS SMAHEAMFNG
WLMGIRTVFT DHSLFGFADA SAILTNTLVL QYSLANVDRV ICVSYTSKEN TVLRGKLDPR
KVFTIPNAIE TSLFYPDPKQ FYGNPTTIIF LGRLVYRKGA DLLCAVIPKV CARHAQVRFI
VGGDGPKRLE LEEMRERYRL HSRVTMLGTL PHDMVRQVLV QGQIFINTSL TEAFCMSIVE
AASCGLHVVS TRVGGIPEVL PSDFISLEEP VPDLLVNALC EAIQKRENRQ LMDPVQKHEA
VSRMYRWPER TMYGIEMN
//
