ID A0A0N4Y5L8_NIPBR Unreviewed; 484 AA.
AC A0A0N4Y5L8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Nuclear hormone receptor family member nhr-23 (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:NBR_0001130501-mRNA-1};
GN ORFNames=NBR_LOCUS11306 {ECO:0000313|EMBL:VDL74895.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001130501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001130501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL74895.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; UYSL01020499; VDL74895.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4Y5L8; -.
DR STRING; 27835.A0A0N4Y5L8; -.
DR WBParaSite; NBR_0001130501-mRNA-1; NBR_0001130501-mRNA-1; NBR_0001130501.
DR OMA; CMELGMS; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF2; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 48..123
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 225..484
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 484 AA; 53516 MW; B188B3C367A7C21E CRC64;
MSSARVELSS TSVAIGPIIV KKEDSTSISS SPVLPTPDGV ENQPQIEVIP CKVCGDKSSG
VHYGVITCEG CKGFFRRSQS SVTNYQCPRQ KNCTVDRVNR NRCQYCRLKK CMELGMSRDA
VKFGRMSKKQ REKVEDEVRL HKQMQEATGI PYMYGEYSPP SQQSSYAAPG YETGLYPHYA
QGAYAAHAVA AAPISYPSHS YGVAQQGAVP ASNGGFPSPQ LSSAAEEDTA AKIVAAFETT
HTQMRNMNPN PTIVDVNRFA SIDFQNRVGI WRQFAVDLTT VIQAIIEFAK MIDGFMRLGQ
EEQIHLLKGG VFELAIVELS SRYSPETQTL SMDNIVLPLH NLNITDQIEA ILLYPVEEKL
PYSLRLLMLL LSVQVRFVQE FHQCLHDLAV CQMTSSEVAL LCAVLLLEPA STEQATCERL
RGVLAQSLAA RVGNDAQRVW DTLPRLKQTA HLHLILLGQL RAQFPAETEA GLPALYKELF
SIDP
//
