ID A0A0N4Y763_NIPBR Unreviewed; 409 AA.
AC A0A0N4Y763;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ion_trans_2 domain-containing protein {ECO:0000313|WBParaSite:NBR_0001197301-mRNA-1};
GN ORFNames=NBR_LOCUS11974 {ECO:0000313|EMBL:VDL75563.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001197301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001197301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL75563.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666}.
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DR EMBL; UYSL01020643; VDL75563.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4Y763; -.
DR WBParaSite; NBR_0001197301-mRNA-1; NBR_0001197301-mRNA-1; NBR_0001197301.
DR OMA; KMALPHV; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF296; ION_TRANS_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..78
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 110..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..152
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 46662 MW; 29FDC7F42D3DB0B8 CRC64;
MESIVSKFYT DLYKSNLRPN RQQPAGGDVP SILPSETTTG YSYAVPVTPF GQFLAIGYGM
LGIPLMVLAA VDIGRFLSHI VLELYAKYQV MSSSLSCSEQ LSTTTTAVLR ARKPFTKERH
EPKTPPRKPS TLEEEDQRDS DVVDEDEEED SEKEKEPAAK RLPLSINAGI LLVFCMMGGV
TYIAAGGKAT FLEAFFVTFN LVANLTMSEM PSDLNHVLTL IYIFVFVTFG VAVLSMCAEL
AALELKDIFL KIHYFGRKIK FKRRHKKEQM EAEVKELLKI IEEIRRRYPE KDRITSLDIL
QYMNEASAER VVLTERRDTI AFIPQAMEML KFADEMDLED RSASRLEEAP LIEKAPHRST
KLIDVLQFSE DIDLEHCFYH ELRKHAREKH REALQLPVDY RPSSSASFR
//
