ID A0A0N4Y9M6_NIPBR Unreviewed; 473 AA.
AC A0A0N4Y9M6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein disulfide-isomerase TMX3 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0001302801-mRNA-1};
GN ORFNames=NBR_LOCUS13029 {ECO:0000313|EMBL:VDL76618.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001302801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001302801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL76618.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; UYSL01020924; VDL76618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4Y9M6; -.
DR STRING; 27835.A0A0N4Y9M6; -.
DR WBParaSite; NBR_0001302801-mRNA-1; NBR_0001302801-mRNA-1; NBR_0001302801.
DR OMA; NSTTQHH; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..155
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 443..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 53384 MW; 7EA36EB47BD701B3 CRC64;
MQQEPYDIEY FASNIEAEYE LRIIRKCMRW SLLLSLVAFI PSCLGSTSLT VVIDLNEKFL
DVSDEGYWIV KFYAPWCAHC KRLLPVWEHL GHAVSDKNLP VRVAKMDCTR FTNACNKLSI
SGYPTVIFFR HGRRIEYFGE RTKEALFNFV VKSAAPIVEK VNAVRLNEIR KDSRNDPAFV
IIGDEQDEMQ GEFEAIADSL FSKTRFFSAS TTSVPTSLAE SGARIAVFKD DSFFPYHGSV
EGLKKWIMAE RWPLMPRASS SNLADIASSG KLSVLVICTE LERFNQSSPV GVFCEKARGA
AEDLRKSEYL WSRFQFAWMD GPDVAIGIVM GNVDAPSMLV FNYSTYEYYL NDDDPAKVTR
ASIVTWLSNL ADGIEKGTAV ALGGRSLPTR IRRIIFEVYS NVSQMFATQP LLSSVLFGMP
IAFLSIICYS ICSADFNVDR EEFYPEDEDE DYDDGEEEVG SSHAVDPNHP KNE
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