ID A0A0N4YCH6_NIPBR Unreviewed; 324 AA.
AC A0A0N4YCH6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Cathepsin F (inferred by orthology to a S. mansoni protein) {ECO:0000313|WBParaSite:NBR_0001424401-mRNA-1};
GN ORFNames=NBR_LOCUS14245 {ECO:0000313|EMBL:VDL77834.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001424401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001424401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL77834.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; UYSL01021290; VDL77834.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4YCH6; -.
DR STRING; 27835.A0A0N4YCH6; -.
DR WBParaSite; NBR_0001424401-mRNA-1; NBR_0001424401-mRNA-1; NBR_0001424401.
DR OMA; DLEDNAC; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF949; PROTEIN CBG17217; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..323
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 324 AA; 36047 MW; 42EF4208B03C7CA9 CRC64;
MTGIKVTAKK EVQIPLRSAG SEDDEPVISK GLKRQIVFRL VVATLLILST VFYAVVMDRP
HRQELQQHPF FDQAIPDRSS LLSLSFYKRL REEATFIRKD PPRLERALPP PDFFDWRARN
VVSPVKAQGK CGSCWAFAAT ATVEAAWAIA HGEMRNLSEQ TLLDCDLEDN ACDGGDEDKA
FRYIHRNGLA YAADLPYVAH RQNTCDISGN TTKIEVAYFL HPDEQSMIDW LVGFGPVNIG
ISVTPDMRPY KGGVFTPSAS DCKNKVIGLH ALLITGYGTS DSGEKYWIVK NSWGNTWGVE
NGYIYFARGI NACGIEDEPI GILA
//
