ID   A0A0N4YDD2_NIPBR        Unreviewed;       452 AA.
AC   A0A0N4YDD2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Mitochondrial-processing peptidase subunit alpha {ECO:0000256|ARBA:ARBA00016741};
DE   AltName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
GN   ORFNames=NBR_LOCUS14622 {ECO:0000313|EMBL:VDL78211.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001462101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0001462101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL78211.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC       mitochondrial processing protease (MPP), which cleaves the
CC       mitochondrial sequence off newly imported precursors proteins.
CC       {ECO:0000256|ARBA:ARBA00002123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYSL01021427; VDL78211.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4YDD2; -.
DR   STRING; 27835.A0A0N4YDD2; -.
DR   WBParaSite; NBR_0001462101-mRNA-1; NBR_0001462101-mRNA-1; NBR_0001462101.
DR   OMA; LYTKVMN; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT   DOMAIN          48..188
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          202..356
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   452 AA;  50075 MW;  AA1AC7C3069C07A1 CRC64;
     MIVQYEIEDM PKKIENIEPL LTDWLHKAAF RDNTLGFSKF TTEEALPKIT EKHVNSYISQ
     HHAPERVVVA GVGVDHDEFV AAVERHFKPG TAAWEKNPEI LLPKLPPLDK SVSQYTGGEV
     RINKDLSTLA IGTPYPNLAH IALGFEGASY KDPDFVAFCV LHMLLGGGGS FSAGGPGKGM
     YTRLYTKVMN RLVVIEWNFS IFPGGVAELP PLDKSVSQYT GGEVRINKDL STLAIGTPYP
     NLAHIALGFE GASYKDPDFV AFCVLHMLLG GGGSFSAGGP GKGMYTRLYT KVMNRCHWVY
     GATAYNHSYS DVGLFCIHAS SDPEQINDLL IVILDQYLSL LKGVEKEELD RAKIQLKSQL
     MMNLEVRPVM FEDLARQVMG HGYRRKPQEY LDNIDKVTAD DIVRVSQRML AGRPSLVGYG
     DISKLASMEM LDEAVARRSL QELVSPKKSF GW
//