ID A0A0N4YDN2_NIPBR Unreviewed; 363 AA.
AC A0A0N4YDN2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Acetylcholine receptor subunit alpha-type acr-16 (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:NBR_0001473901-mRNA-1};
GN ORFNames=NBR_LOCUS14740 {ECO:0000313|EMBL:VDL78329.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001473901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001473901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL78329.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UYSL01021472; VDL78329.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4YDN2; -.
DR STRING; 27835.A0A0N4YDN2; -.
DR WBParaSite; NBR_0001473901-mRNA-1; NBR_0001473901-mRNA-1; NBR_0001473901.
DR OMA; THEMGAT; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF578; ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE ACR-16; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 3.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..363
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036295874"
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..76
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 70..124
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 127..175
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 182..238
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 363 AA; 41650 MW; 026DF3B582512ECB CRC64;
MERWLLVCTA MTITGIGWAS YDERRLYEDL MRDYNSLERP VANHSKPVTV YLKVSLQQII
DVDEKNQIVY VNACVDANFD STYPTNMVVY NSGDVHWIPP GIFKISCKID IEWFPFDEQR
CKFKPAKKGF DISEYLPNGE WALPLTTVSR NVKFYDCCPE PYPDLTFYLH MRRRTLYYGF
NLIMPCILTT LMTLLGFTLP PDAGEKITLQ ITVLLSICFF LSIVSDMSPP TSEAVPLLDS
NNSHKLSLQM RSVLLYWLPW LLRMKRPGVE LSYATLPSLF NAKLKSHSES LIRNIKENES
NTSRSNSLEI ERRVHQYMSY AGVMNGVSPP LTVPHSQISA PLDLGQQATL LILQRIYHEL
KVG
//
