ID A0A0N4YHL6_NIPBR Unreviewed; 645 AA.
AC A0A0N4YHL6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=CULLIN_2 domain-containing protein {ECO:0000313|WBParaSite:NBR_0001636001-mRNA-1};
GN ORFNames=NBR_LOCUS16361 {ECO:0000313|EMBL:VDL79956.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001636001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001636001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL79956.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; UYSL01022159; VDL79956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4YHL6; -.
DR STRING; 27835.A0A0N4YHL6; -.
DR WBParaSite; NBR_0001636001-mRNA-1; NBR_0001636001-mRNA-1; NBR_0001636001.
DR OMA; NVVQSCF; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 319..518
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 37..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 546..580
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 75040 MW; C216CAB38C2E0A7D CRC64;
MSDLSDEMLS DEESAEMFRQ AFNDGEPEYM FEQLIEGPNE EQFDHEKERD ESNESLVDVR
AARQTSRGLP TVKKLTIKNF RRKNDDVADL MATGWLTLEA SINAIQTKQH VTTNLEQLYK
VDRYLLKALL RMLRTLDLYK QAFEEEFLTN TSVHYTHESM SLVRSLETVD FLLYVERRIK
EENERIDLYL DESTRTPLLT RAEKCLISDH MQEVVDNGLP LLLNDNRVSD VSRLYALLCR
VDGGVALLKT GFSSFIKKVG QAMIMDLQRD QTMVEDLMAF KDKLDVFVET CFGSGEDKMK
FAQAEKDAFD YFINTRGNKP AELIAKYMDA RLRSANKEAS DEQLDQLMNK VITLFRFIQG
KDVFEVFYKK DLAKRLLLGR SASVDAEKIM LSKLRQECGA GFTQKLEGMF RDMELSKDLG
VAFRNVNVPH HLSCSLQLYE KFYDSRHTGR KLQWQPRLGQ CVLKANFRRG VQKELKVSLF
QAIVLLLFND QQSWSAADIV QATKLDQKEF VRTMVSLSCA KVRVLVKSPM NKEIKDDDVF
TVNTDIKEMR FRIRISEVQM KETEEEYKAV EEEVNQDRQY QIDAAIVRVM KTRKKLNHQL
LISELFAQLR FPVRAADLKK RIGSLMERDY LRRCDEDPNL YQYVA
//
