ID A0A0N4YKQ8_NIPBR Unreviewed; 1266 AA.
AC A0A0N4YKQ8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=UDENN domain-containing protein {ECO:0000313|WBParaSite:NBR_0001764401-mRNA-1};
GN ORFNames=NBR_LOCUS17645 {ECO:0000313|EMBL:VDL81302.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001764401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001764401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL81302.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; UYSL01022886; VDL81302.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4YKQ8; -.
DR WBParaSite; NBR_0001764401-mRNA-1; NBR_0001764401-mRNA-1; NBR_0001764401.
DR OMA; KVTQEMY; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1266
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041079307"
FT DOMAIN 1..429
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 623..921
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 926..1032
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1140..1262
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 255..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 142589 MW; 6403205710C59886 CRC64;
MSKTLCLITR LPLVCSTTTI LRTLHEILTS GSQPELPLES YIYWLLNEIP LPSPGTTLKV
SMLDSTILVQ RPGSRELPIF DDSLAAMFQF ITVEKFLRLF ACFLLEHQIL LCSKDYSRLM
CVSEALSALA FPFRWQMVYV PILPYSQLKF VEAPVPYVMG WCYEDSVPEF LFQSNVCVLD
IDTGRTEFPE DLPPFPGAKQ LSQEIKSALE RYSTWDEMSK SVISGTTPSA TSSPATAVAN
RGNLVRRTEE WSSKRMSRSF DRDDATTNDD IHDSLLSPRP SRADLTPLPL ENVLRNNSTV
ARVAEIARRA GVLVDVQDLE QELTCKDQYT NSPVCKQYFQ NARLNNAIRE CVLNRIVCML
YSYEHFVVGG QGCSDKEAFD ESRDSLVCFD KASFLSDQPD SHLGFLAAFL ETQMFTSFID
AKILSQWEPP DENLVLFDSR IAAMREKLGL SMVRTPTYES TPPFAYTGWL KRWCFQFGGF
KKGALVEELI SKREETLDYV VPGPHELAGA VAMRYDGIWP EQLNTALLEG AMGLSPAPSP
WKQRYPRLRP RQQENVGAGG RPTSTYGGAG LVGDSPALVA QQQLKFVDQL LRETKGKTKR
MLVDKMGKEA VQLGHLDAGI TGVEENTLVA SFCDLLERIW AHGLVKKQGK SSLWSFVLQH
QDLEKTVLST RTMSSSMLTP GDGPRSTIKR TPSLPHCEVP APVIVQPSNE NDFAGAISEI
VESIQRELGK GDDESSPAWS RSILRAANFL ADKLSNNPRE ESRGVSRNTP SQKAQGMQSS
TMRKSNSVGD FTNPAWNSEI GSTPDVAGSP RRRSQSRPRS PDSGPRILLA PLPNHIAYDL
KNVLRMTEIK TDIGYARAFV RLALERKLLH RHLGTLLGNS RLLSELYKPY AFVRCEDERE
QFLYHILSLN AAQFRCFTNT FTKTKMDYQV VIVTGGWRGS LPAVWVTVGG SLCSSPQINL
PANTPLFKFD HKNLGVLSTL RIGHAPGTER PPKWYLDYVV VRNEITGQMY RFPCGRWFGQ
GVEDSRWFGN GCDISLERFV SSIKWRFRAI NTTIDRLLVA EPVCEDENSE SSFTTVPNSP
ARSARRGRVS SRSQTPQRER SPSQNRHDST ANRKTRINEI QQLLGEAVNA LVKYFYSEKN
SKSELAHLLC EKVCVWLMDL LRRRDATWTR EQRELVTHAL RLVRRISDRG ALGKDAKFHV
FVLLTMRDHM LSGFLQLMAW TPVTAQLFDE PSFLRTPAHL TYLSRLLDSL NEFTFTLDPS
LTYGVV
//
