ID A0A0N4YMW3_NIPBR Unreviewed; 592 AA.
AC A0A0N4YMW3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=HBS1-like protein (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0001854701-mRNA-1};
GN ORFNames=NBR_LOCUS18548 {ECO:0000313|EMBL:VDL82273.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001854701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001854701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL82273.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; UYSL01023507; VDL82273.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4YMW3; -.
DR STRING; 27835.A0A0N4YMW3; -.
DR WBParaSite; NBR_0001854701-mRNA-1; NBR_0001854701-mRNA-1; NBR_0001854701.
DR OMA; CFETEHR; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF188; HBS1-LIKE PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 163..387
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 64397 MW; A60519DC7B197D6E CRC64;
MSSGGFTIGT KLSEFIPEEK NYPDEHDKTI SQDEEMFDMD EEAGAADKPE QFTAPSTSAA
QARIDPGPPP GFDFPQRPSK PIVISLTTPV PQEEKPVIPN ITNLRVSEPA RSDSKSPTRK
KTGTNIQLGN IPANSSSHRL SQLAAITSTP STPRRSRRRD EGKELVNLVV VGHVDAGKST
LMGHLLCRLG CVDQRTIHKY KQESARSGKA SFAFAWVLDE TEEERSRGVT MDIAKTTFET
NTKRVLLLDA PGHKDFIPNM ITGASQADAA ILVVNSTRGE FETGFENGGQ TREHAMLLRS
LGVGQLVVAV NKLDTVDWSE DRFLEVQAVL KPFLAKQAGF SNVRFVPVSG LSGENLSERV
PDDHPLRKWY SGECLIELID TFSAPSRACD GPLRIVINDV FKATTNQLSL SGKIESGEVE
MGDKVYIMPN ADAAVVKACS NDDGGAVDTC IAGDQTLLTL NGLFEPDTIH AGHIIVRGGQ
DALMPCKRFV ARIVVFDIVV PIMKGTRAEL YCHSLCEPCT VVKLISAINK ANGEVIKERP
RCLSKHMSGM VEIETEREVA IDSYTNCKAL GRITIRAGGQ TLAAGIVERK LS
//
