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Database: UniProt
Entry: A0A0N4YTA3_NIPBR
LinkDB: A0A0N4YTA3_NIPBR
Original site: A0A0N4YTA3_NIPBR 
ID   A0A0N4YTA3_NIPBR        Unreviewed;       215 AA.
AC   A0A0N4YTA3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   ORFNames=NBR_LOCUS20476 {ECO:0000313|EMBL:VDL84213.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Heligmonellidae; Nippostrongylinae;
OC   Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0002047501-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0002047501-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:NBR_0002047501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDL84213.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; UYSL01025176; VDL84213.1; -; Genomic_DNA.
DR   WBParaSite; NBR_0002047501-mRNA-1; NBR_0002047501-mRNA-1; NBR_0002047501.
DR   Proteomes; UP000038043; Genome assembly.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 2.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038043,
KW   ECO:0000313|Proteomes:UP000271162};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713}.
FT   COILED       20     50       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   215 AA;  24760 MW;  07A6A1F791A958F6 CRC64;
     MIRILSEVFC VGDESSGSLK KREAEREKEL IEKMERLKRL KEMLKKKKKL EGKYTDPTSQ
     AARKECPVRI EQEVLRRNID HNFTGGIITV FYERKFGLCP YYDNDSPDAP INGGLPQNVQ
     LAEHLKRVEQ QIQEQIPDAN YDGLAVIDLE EKFLVETLKT VKNLRPKALW GYYIYPFCNA
     KAGEEEDDYS CSAKAQEYND ELVCSEIGRL IGLFG
//
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