ID   A0A0N4Z9Y7_PARTI        Unreviewed;       844 AA.
AC   A0A0N4Z9Y7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=A2M_recep domain-containing protein {ECO:0000313|WBParaSite:PTRK_0000419500.1};
OS   Parastrongyloides trichosuri (Possum-specific nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Parastrongyloides.
OX   NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000419500.1};
RN   [1] {ECO:0000313|WBParaSite:PTRK_0000419500.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   AlphaFoldDB; A0A0N4Z9Y7; -.
DR   STRING; 131310.A0A0N4Z9Y7; -.
DR   WBParaSite; PTRK_0000419500.1; PTRK_0000419500.1; PTRK_0000419500.
DR   Proteomes; UP000038045; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   PANTHER; PTHR11412:SF175; TEP (THIOLESTER CONTAINING PROTEIN); 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          40..132
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          696..785
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
FT   REGION          808..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  93632 MW;  610F8EBEC4111A1E CRC64;
     MNRLDGPMPV MMMSSAVKET AESSLLSPLN IKIRSEFPET WVWSDFDHVS DNGTVTFSTK
     VPDTITSWVS SAFAINENLG LGISPSNPKL KVFRPFFIRL NLPYSIKRGE QFALQVLVFN
     YMENEQDVEV TLKQKENSGF EFVSNDLTSI NKNDSPYINK RIISVPGGGI SKAVYFPIVF
     NQVGDIMLHV LAQSQNAGDA IEMPIKIEPE GYRVDRNVPL VIEMSGDNNG SSNNSSEIIK
     ENGEDIGMVN STNEYQFIKT VNMIFPSDSV QGSKFAKIDV IGDIMGPILS KLDSLVRMPS
     GCGEQNMLNF VPNIVVMKYL SATHKNMPAL SKKAIAFMEA GYQGELTYMR DDHSFSAFGK
     SDKHGSTWLT AFVLKSFKQA QEYIYVDSVI LTHSINFINA QQLIDSGAFS EKGEIHHKDM
     QGGAQNGGVA LTAYVTIALL ENGVKNDKAI QYLENNLNDI IKNNGTEDST YTLAVTTYAL
     YLAGSSRAGD GLKELENRKI TTNDGTTYWS TTPKSNGIEK SVDKDTSLYF YQPKPADVEM
     TAYVLLSYNK LGDTHSASSV VRWLTSQRNS LGGFSSTQDT VIALQALGEY AERVYSNDID
     AKIKIELTNN EEHTFEVNSE NSLVLQSYII NNPEGSITIK GSGSGVIFIQ IQYSYHKTST
     RDDSAFNCSK DIKEVRSGNR IQMDLCCNYN KNGGKSNMAV AEVNTLSGFK YDIDETNKLT
     DIDDLQRIDL DNDDTKVNIY FNPLGSNPVC LSLYSDKAYQ VVDQKPAQMV LFDYYNPEEQ
     LKSTYSIKQS RTLRDICNEC WSNMPEDKTN NASLDSSNSK SFTTSGGSSN IRKAATSFTT
     GSRD
//