ID A0A0N4ZB89_PARTI Unreviewed; 936 AA.
AC A0A0N4ZB89;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ras-GEF domain-containing protein {ECO:0000313|WBParaSite:PTRK_0000480200.1};
OS Parastrongyloides trichosuri (Possum-specific nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Parastrongyloides.
OX NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000480200.1};
RN [1] {ECO:0000313|WBParaSite:PTRK_0000480200.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR AlphaFoldDB; A0A0N4ZB89; -.
DR STRING; 131310.A0A0N4ZB89; -.
DR WBParaSite; PTRK_0000480200.1; PTRK_0000480200.1; PTRK_0000480200.
DR Proteomes; UP000038045; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 550..669
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 701..932
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 161..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 108772 MW; 813E29DE69C6B04E CRC64;
MANGISCITS ESIFKLLNVL ETKNFEIINN AFNNVLNTFF NINFDNDNEK HKFAQHLSPL
IEWWDCLSVK ICCDDSYFIT NEDINRGRKM LHDIKKYISI SSWQVSVEEK DDEDKSTGGV
ITDMIVYTLP MLEKNSNNDD FCSLMKNLMN RQIEVFKPNF EIHEGDSDDN ESDKNEPKCE
EESETRKEQH GSKTTEEEIT KTPDGREIRS TKTRIVNSSR TSKNVTVRRY GNGLDDIRTN
FFDVNRSHNE DSDEEFFETF KKPSSYGSSS FGSSNNSSFF KNRKSLGFKD FDTNDFLPTD
TLSNVNDNNS NPDDSHNHNN NEESQSNEMQ KIKKVDHSSA TLQVVEKTKK KNGKLKFNAA
AHKLDTKQLT AQQKETYDGD ELIRREGDGD FEENTTIGAG DVNPEALMNL GTVNRFGLHD
KKEFECGNYD NNGSYIKGLT MTSYLLVNDS ISNHEEQFRK KLQFEFRNNC PLKIDNIKST
DKEINLHQLL ELADFDEMGK EATEKVNKLS KSKDTVDNIL SLTEDLSIFE ELNVKPFLTF
VIKIDDKGEV AEICRGGPKD ALIVFATQNE APLLFKEAFL STYRGFVSTL EVILHLIYRF
QYLLDKNDSQ QNRNAHSTIS VIIRIIQDLS VSEMNEKIIL TLTQLYNTLY TNSEIQFLRI
LRKIIFTKIV SFYNSKNDNI LPRQVKCMLD GQKVKYFLNM RSLKLAQEIT IISSKLFHNV
KESELLWWSI DQSNSHSYNL RRLTISFNFI SFWTRTMILM NDEQKIREKV FAKFLKIGKY
LKHFGDLNSY LAIIAALDCG PINRLPWNKT IKEEMKEHRL IMSSNYSFKN YRQLFSQCKP
PCIPYIGLIL QDLTFIYNGA IDTLPDKERN GLNYINFVKC FKQFTILESI RKLKMWDYSF
ESNEEYKNFL NNFVEHYSEE ECWIRSEMIK PRGSKN
//
