ID   A0A0N4ZGQ5_PARTI        Unreviewed;      1599 AA.
AC   A0A0N4ZGQ5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Integrase catalytic domain-containing protein {ECO:0000313|WBParaSite:PTRK_0000696300.1};
OS   Parastrongyloides trichosuri (Possum-specific nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Parastrongyloides.
OX   NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000696300.1};
RN   [1] {ECO:0000313|WBParaSite:PTRK_0000696300.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   STRING; 131310.A0A0N4ZGQ5; -.
DR   WBParaSite; PTRK_0000696300.1; PTRK_0000696300.1; PTRK_0000696300.
DR   Proteomes; UP000038045; Unplaced.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00354; HMGI_Y; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          607..790
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          1290..1459
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          60..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..161
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1599 AA;  185298 MW;  CB045E7EB3526CDA CRC64;
     MSKDTRDTSE YNTILLTPEP TVKKRRVQEN SCEMETDDNQ TSTIIRPNRD ATLDASNQIN
     ITGSAGPLKT PVTTRSAPTK RPRGRPKKTV ICSPPRWERE FNSLRKDVNQ LASNMESMMR
     QLLTLNLSLN HSQRDQSNNN PFVRPIINDD NVPTTVSDDD NDNGENVVDN NDDLEDQYSI
     LSQPQIRKSK RDIDVISAYT KDEDYDTDAT FGKTYQIRRD PEPSNVLMKE ENIFKIQTMI
     KPFKGDNWMG WLRILELTFD KMNIHSDSDR LYLLNTKLDY KILEENDKAI SRCKSYMDLR
     NLLTKQYSNK STIKSAEIEL KALEVMKLND HKDIDKVARK ANHLLRTAYS FMEDTQRYKR
     VAEILGSKLP MQAQLMIVGH SPTSLEDVIC FIKDLYQKSN QHTLRNNRPS NNAHKNNRID
     KKHDNKDPYN KPSFKGDIKK SDYTKPDSKT SNFKSKAKKP AHFVQYNSGN ENEYMNKKHT
     QCYNVTSSSD SAENLDYDVI LGTNLLRTLN IWLNLASGEL KCGNPNTDAT YLTLVHNTDK
     EILKIVDTLY NEFKNAFSTN DMDIGKCTII AQPQTFRPIE TMNKRAPYYE TPLHSQPDAL
     ALAQQFVDCG ILSPNMGIIV HPVLLVKKPS GKFRFVSDLR KVNSIVDMID ARITSPLTLL
     SSLRTFVYLS QFDLVSGFHQ VHLQEKEKSY YGIKIGEHYF TYNTLVQGGR NSSIQFVNVM
     HQVYSTINDL SHSKLYIYID DLILITFTNR EDHITALKLF LDLTISAGLK LSPEKTTMLS
     TETIFLGNHI TCSHRKIDNS HITKLLNNKK PETPSQLLSF LQSIQFYREY FRSIQVDIAE
     LYKYTTTNRS CKNKKLVMPT SAWKHYDNIL NELKNNSGLH LFIPGYPIEL HVDASSYGIG
     SMLCQRVPAH IGYPDEYDET DSKEVLIPLS FYSKSLPPTV NGRCSTYTEL FAIHRSVRYW
     SYILTNVEFS VFSDHKPLLH LRMSTSIHKF VEMITELEGF NFTIYHVPGE HNTFPDYLSR
     IRSPPPKTLE SCTLKDINKS PTHKEPILNL LIQFHKYLHS KEFSQYQEND LLLMELYKKK
     QFGRMKVRKD KFDNTLKILA FVKGVDNGEA WLPLITWSQL EKIFPGLDGS IITFLTEFAY
     IIQDKKVKDV YKDKQVKEVF NIMNLTPLKI NELSRLELKS HYSDDEWLKK VIDSKEMKYR
     NFKVVHKDGL YFAIDTSSCD NEELLLYIPE KLETRLFDMV HKESNHPNYD KMRILLKSIF
     IPKKCKKICD YLKKCKACLS RNIIPNSDKL IQRPMKMENV YETLSFDYMG PIESDKRNRK
     HVLVVICNAS TFIWLFPMVS TGSQELLKKL NKLFTVFGRP KRIHRDCSKG NTSKEVEDYL
     KSWGIESSTS IPHYSRSNAL VERKIRDIQA ILSKKLMDYK MSKCLVTWSD LLPEVMYQAN
     VTPILRTDIT PFQLMFGRIG RNNLDLFLKS FSPYVNNKAD EILQGSKIAI DIVREQQKES
     RNRQLERINK NRVPTIEVKK YQIVYLKNEN ERKGKLEPNY FGPYFVREIH KDFAIIHKVD
     GKGQDIKAHL RSLKLTSDYL DPSSAKIRLN KGGITHTYI
//