ID   A0A0N4ZI24_PARTI        Unreviewed;      1971 AA.
AC   A0A0N4ZI24;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=acetylcholinesterase {ECO:0000256|ARBA:ARBA00013276};
DE            EC=3.1.1.7 {ECO:0000256|ARBA:ARBA00013276};
OS   Parastrongyloides trichosuri (Possum-specific nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Parastrongyloides.
OX   NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000758100.1};
RN   [1] {ECO:0000313|WBParaSite:PTRK_0000758100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
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DR   STRING; 131310.A0A0N4ZI24; -.
DR   ESTHER; parti-a0a0n4zi24.1; Cholinesterase-like.
DR   ESTHER; parti-a0a0n4zi24.2; Cholinesterase-like.
DR   ESTHER; parti-a0a0n4zi24.3; Cholinesterase-like.
DR   WBParaSite; PTRK_0000758100.1; PTRK_0000758100.1; PTRK_0000758100.
DR   Proteomes; UP000038045; Unplaced.
DR   GO; GO:0003990; F:acetylcholinesterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 4.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000997; Cholinesterase.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF370; CARBOXYLIC ESTER HYDROLASE-RELATED; 1.
DR   Pfam; PF00135; COesterase; 4.
DR   PRINTS; PR00878; CHOLNESTRASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 4.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867}.
FT   DOMAIN          6..502
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          588..1033
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          1055..1537
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          1574..1925
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   1971 AA;  228221 MW;  5BDA87F749BDD977 CRC64;
     MTFFTTVVTN CGHYIGKNLN IEREYSVIEF LGINYGEAPV GNLRFEDPKP YKCLKGQIYL
     CEEYGPLCPQ VRVYSSNISY SAIAFNKLHA SEDCLSLNIW KPNIKGDLPV LVFFHGGDFM
     EGSGNYKIYN GAHLAYHGKV IVVTVNYRLN VFGFAQTIGG LSIHGNMGLK DQQLALQWIQ
     KYIYYFGGDR HKVTIIGAEA GAASVQAHLF ASESFGLYKS AIMFQGHMTN VKYWKPYKKI
     QSYTEEFIKM LGCRKKYPQE DLVCLRKKTT SQIVDAAERL YKKNSAHEFG SPFAISPYDL
     NFFKKNLTNE FANVNSGSMN INTNAKVLVG RAKNGGVLEI KKINYTNITS VYNPKRWAYY
     ASIDNDTYWH ILEDVAKRIK VPLVTSKRLD EFYKKYKDFP EKLIRLFSDL FNDCDLRKFV
     SSAYSLKQYP RLFMLDRPSS ILLKEGYEWF GTTSIEFLEY ILGNPYRSKN DYHLWQLMYE
     KKISKDIMSL VINFINNSAI DERWSYSDYD HLKERYINNK FDLKIYDMRK SKISLGICKL
     FDNIIPWNDL KEFMTTRTPT TTTVELKTTT LTNDKKEHKE MYFGNNGIVG EFLGIPYAKP
     PIGNLRFQNP QEPYCHNFRT RIVFDKYGKS CPQMITSNLE KFEGTIKKED TSENCLYLNI
     WSSLTASRKP VLVFFHSGGF NGGSANLDIY NGSVLAFETK SIVITVNYRL NVFGFAQSTN
     GLDIPGNMGL KDQQMALKWI YKHIGKFDGD RSRVTIFGIG AGAASVSAHL LSEDSFKYYK
     GAILISGHMA SVKYSKSYNS IQNYTNELIN RLYCKRKYSY SAGIKCLRSK RKDHILKEAL
     NIYEKTKKNE FGPPFVISSF DRNFFKRKLN DMFVDEPYSS YLFNRNARVL LGHTENDGLI
     DLLYNHYLDV VSFNVRTRIF DLKTTLVKQK NIFQDVVKKL CLKSDKRKLI EDIYSNYTKN
     KEKVIKLYSD LFTSCDLRQF TRNATFYLKD KPRVFALNKT STMRSKDTFL WLGSTILEAI
     EYIFGNPFRH PDQYRGGTIV KEQGYSLMVY NDQYGNNSIM ELLGIPYAKP PLDSLRFQNP
     QEPKCHAKQT KIVFDKYGKS CPQLSVRTTS NKKDYLNYNM HTSEDCLYLN VWVPFLIKSS
     PVIIFFHGGG FIGGSANLDM YNGSYLARLT QSIVVTVNYR LNVLGFAQSS GGSTIPGNMG
     LKDQQMALKW VHDNIEYFNG DRERILIFGI GAGAASVSAH LLAPESFKYY KRAMLLSGHM
     ANAKYSKPHK DVQLYTEKLI YKLGCRYERK PNLELKCLRK KHVHDILNEA EKLQKDLKTY
     DFGSPFSISL SDLTFFKRKI NNKYIDKPHT TKGFNIHAKV ILGHNGNDGV LDLLDEYFND
     VVVYNTTTKI FDLTIKKKIY ENILDDLIKK LKIPFLNKRM LHKAYSNSTR RERVMRMFSD
     IFYNCDLKEF TFDSLYLKNF QRGILLNKTS AIKTKKGYLF LGATKIDAID YIFGNPFRHP
     EQYPKDKLNE EQNYSHNLIK LIGSFANKNE FQYSWNNSDY EVYRERMANE TFNVDKVYMI
     ESPIQPLMCK LLSGTVVVTV NYRLNVFGFA QSQGAYYIPG NMGLKDQQMA LKWINKNIKY
     FNGDKRKVTI LGIGSGAASV SAHLMVKESF GLYKKAIMFS GHMANVKYSK SYRTVQDYTE
     KLINRLKCQK NQLKCLSKLS THKIMNEASK LYKQMSRNEF GSPFSISLFD KTFFKGHINN
     KYINLYTFNS YTKILVGHTK NEGSLALLSG LYSYVFVYNS KKWKYDIIVD NVSYKAILND
     VVKKLNLKVN NWSTINETYS NYAHNADKII RLLSDLFNDC DLKTFTFIAN QRLKNKIRVL
     LLDKAPSSLF EEKYEVFGTT PQDIIEYLFG YPFRHPNHYR QNNLEDEKNY SLKLMEFISN
     FTKTYTFDEN WKSSDKNIFR ERMVNETLSW NKYIILESPL NTNSCKILKD F
//