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Database: UniProt
Entry: A0A0N4ZIF3_PARTI
LinkDB: A0A0N4ZIF3_PARTI
Original site: A0A0N4ZIF3_PARTI 
ID   A0A0N4ZIF3_PARTI        Unreviewed;       682 AA.
AC   A0A0N4ZIF3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE            EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
OS   Parastrongyloides trichosuri (Possum-specific nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Parastrongyloides.
OX   NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000770700.1};
RN   [1] {ECO:0000313|WBParaSite:PTRK_0000770700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU361147};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR   AlphaFoldDB; A0A0N4ZIF3; -.
DR   STRING; 131310.A0A0N4ZIF3; -.
DR   WBParaSite; PTRK_0000770700.1; PTRK_0000770700.1; PTRK_0000770700.
DR   Proteomes; UP000038045; Unplaced.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF244; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361147}.
FT   DOMAIN          37..96
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          102..500
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          561..639
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   682 AA;  75131 MW;  3D41E5FB63FA18DC CRC64;
     MSDCKVKFEL EGSRGSRLFQ PPSNLSASAH IKGIKSYHEK YRSSLNDSDK FWRNVASELY
     FEKMTDNGLE WNFNKDKGKI FVNFMKGSKT NIAYNCLERN IARGLGDKVA FKFEGNEPGD
     EDSITYKQLL EKVIAFSAVL RSKGVKKGDV VAIYLPMSFE LPIAMLACAR IGAIHSIVFA
     GFSSESLANR IIHCQAKVLI TANAFYRSNK LIDLRALAVT AVKICGDNKY KLDAMIVVNH
     SEKITIPSGA PQPSTSAGPL DIECSWDSEL KQAIGVQSPV EWMDAEDPSF ILYTSGSTGA
     PKGIVHTTAG YMTYAYYTCK IVFDSQDDDM YWCTADCGWI TGHSYVVYGP LMNGMSSVIF
     EGVPTYPDAG RMWNIVEKYK VTKFYTAPTA VRCLMGFGNE MVSKYDRSSL KIIGSVGEPI
     NPAAWEWLYY VVGEEKAAVV DTYWQTETGG HVIVPIPGAI PTKPGSATLP FFGVVPCILD
     NDGALMEGPG EGNLCFSRPW PGISRSCWAD HERWEKTYFS SFNGYYFTGD GSKRDDDGYY
     WITGRVDDLM NVSGHLLSTA EIESALVAHP DVSEAAVVAA PHDIKGSFPY AFVTMKEGSK
     LTPEVVTQLK LTVRRKIGAI AVPDIVQEAP GLPKTRSGKI TRRILRKIAE GDVNADFGDT
     TTLVDESVIT KLLSNRPESR TG
//
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