ID A0A0N4ZKF6_PARTI Unreviewed; 5919 AA.
AC A0A0N4ZKF6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Obscurin {ECO:0000313|WBParaSite:PTRK_0000858900.2};
OS Parastrongyloides trichosuri (Possum-specific nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Parastrongyloides.
OX NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0000858900.2};
RN [1] {ECO:0000313|WBParaSite:PTRK_0000858900.2}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR STRING; 131310.A0A0N4ZKF6; -.
DR WBParaSite; PTRK_0000858900.2; PTRK_0000858900.2; PTRK_0000858900.
DR Proteomes; UP000038045; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 53.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF07679; I-set; 49.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00409; IG; 49.
DR SMART; SM00408; IGc2; 35.
DR SMART; SM00406; IGv; 9.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48726; Immunoglobulin; 52.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50835; IG_LIKE; 39.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 63..127
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 154..332
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 529..598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 608..697
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 709..797
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 907..994
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1099..1189
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1706..1799
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1805..1893
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2002..2090
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2094..2185
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2193..2282
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2321..2416
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2427..2516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2612..2708
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2716..2805
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2823..2914
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2930..3019
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3037..3126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3144..3233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3251..3340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3358..3447
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3465..3549
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3593..3684
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3694..3786
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3882..3964
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4061..4144
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4241..4324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4421..4504
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4597..4685
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4690..4777
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4786..4874
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4878..4968
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4980..5070
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5187..5277
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5294..5383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5388..5492
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5507..5597
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5616..5707
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5735..5823
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5845..5919
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 27..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1200..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5919 AA; 659157 MW; B00B897E6265BFFB CRC64;
MAMRRQKQLE RKYSSFRKYT SSEDINYRNR TSRSAYRSES VTSHSDKQGR SSSTEIITGS
ETRSFPVYVA LQDFVPEEGD VDGIPVDQGQ IVEVLDSKNP SKWLVRTKAK PQKTGWVPGS
YFESPTQYYK QRKVTRELAE PNPSLTPEEE AIQKRDQAYG DLLKIEEEFV QSLGNLIDDF
VRIFDSPRVP DEITKNKEIL TTCLKELHNF HAHVLLKGLE YYSDNPGKVG HTFLRLEKDF
DSHVIFEKDY ETILKIIEIP EIKDFLQIIS DKTTAGVKTF KGYLEEIINI IPQYANFFKE
FIKYSQRANC STKSMVKALE VIKLIPKRGK DLQILEKIEN YNGDVTRLGE ILRQDNFQVW
ERETPLEDQL LFLFKNKIMM VTPIPNKDSF KHYATLRLDK YTVREHTIDI NSLVIQPNES
GLPFFRVKPT DSKNQDIIIK AWEKEITEMQ EILDPDEGPS SAKKTKSPPV ISPTASSASI
CSGFSGTSSF GTEWSQTGSN LEFISASGKI CKTQYGFRSF LSQGGAKLCL KVTGYPLPEI
TWYKDDVLME ETERIKFYSD AEGHFALCFE GILESDTGRY TCIAQNEFGS ASTSAQFKVI
KAEKEAAPPV FVTKLKDQEC VEGDIVCLEA EVDGWPEPDI VWLMDDSPIQ QSSDFKILYD
GRNASLEIRD AQPDDSGVYT LKIQNEYGTA QSDAILHVEA DPDKNYVSPE FQSTIDDVEA
DEGDTVKFKA VMTGDPEPEI VWMINGIPLT ESEKIKMIQE DGICILTIKD VTRFFDGKVT
CQAKNRLGST DCNARLKIRI PPAAPNFERH LQSKLVQEKE TITFECEVSG WEEPKVDFYL
NGKLLVHGEN RVEIIKNDTI YKIIITDCSI ELHDGELVGK AINQHGSAES RARVTIEPPD
ESSKCAPTFL KDIEDQTVVE GEKAIFETTV KAHPPAKVTW LINGNIVDSN HDGIEIEVCN
CDHKITIDSA QYAGTVLCRA ENSIGKYETK ARLIVLPKVV PKRPPVIIEH LKEVIEIETK
TAIFEVRASG EPKFEWYRNE ERIYENERIE IREFDGSSKL KITNLKIEES GSIKVIARNE
VGEAISQTTL KVEQKPKAPE FIVTPEGDSS ERGKEQRFYA LAKGHPEPTY TWFINGRKVI
PTTVEAKVEI GEKNTSVLII DTTHMEDLLK IEVIAENSAG MAKYELTMEV KRYEQRMESQ
TESKIEESKI QETKSEQVHQ ESVKEEIKEQ AAATVIKSSS SSSTILEERY HEEQTTTSGS
VATQGITMIP AILVPVAMIG VTGVSYGNGN IVEEVETYET TTTTTTDTAT TTTTKKEIKI
TKTLSDQNIT RGDWANFNTV IENASNVMWL FNNSILTPGP GVQISSTETY EYNLALDTTD
RPSGDITCRA ETQTEEGTKV VEQTVKMTVD EKIEKPEVTE GLKKVNVSEG ESFTVGVVVS
NKAQFAWTLN GEVMEDGRQG IHITADDNKS TLVVNEAQQS HSGEIKVTAE NEAGKAESTA
EVVVEKKQTP ARIEKGLESK EVNENESVEY SVKVSGFPEA SVKFLINGQP VQDNVIIEKR
GDEHILKILN VKKTDSGKVE AVAENNRGSD KSSADLKVIP TPVKPSIKTP LYDKDVEEGV
PVRYDIELDE YDGQTTLDWY LNDKKLDSDG NINIVDHQNG SFHINIRSPT EAMTGTLKCV
AKNKAGEDSS TGKLNVSKPK PPGSAPQFIK ELQQKDVIEN ESVKFSTVVT GETPITITWY
LNDKEVVPIE EIIKVKYEEE SGKTSIRIYK PALDQTGQIK VKAQNKYGEV IATTQLNVTK
KLELPKFTSD MKSMQVVEGT PATFSCSVLG EPKPQCDWEF NGEPIIDNDK IVATQSGDTY
TLTFLEPTLD TVGEVAMVAK NSAGVKKQIA TLSVRELGCA PTFAEPLKDI LVNENETVLM
TAKLGKTKPE ATITFYKDGV EILPDNEHIK ISKTDDGYMK LSILQAKTSD QSKITIKAEN
IFGVGETSAS IGVEKIRAQK KPEFMSDIAP QTVREGDSLT TKVIISGNPD PFVKWYINNQ
LVCKTEDTEL TSDQGVYSMT IHGCSTDMTG TIKCVAYNKM GENVKEGQLT VIAPIPVEFE
SCLCDATCRE GDTLKLKAVL LGEPMPEVSW FIAGKKLEET QNIKIHQDGS TYTVTIKDIT
LDFTGEVICR ATNEFGSAES KAMLLVLPRG DPPDFLEWLS NIKARESSTV IHKVVFTGDP
KPTLTWYINN EEIIPDDNIT IVTNNDTSIL TIKKFNPYKH SGEIICKAEN EAGEVSCTAT
MAHYTSDMYS ESESEAMADD IVTGDEGTDI QSDVEEEYRV PTPIMAPMFI KKLKDTKANK
GQQAIFECVV PNTKGIVCKW LKDGKEVELI ARIRVASQII EGGKLEQLII DDCQPEDAGE
YTCVIQNEAG TEKCIAKLEV IDSDVKPTFI SQLKDQECKW KENVTFECTV SGAITSKCKW
FKEEELIQSS EHYTIIAEEN GTQKLKINSA KLADSATYKC LLEDKSGNIE TSAKLKVKKL
SSQTLSLHEK LVLQCSVTGL PQPTVEFYAN GERIQTGNGV SVQHDANNIH WRVVINSIEK
EFFTTYLAEA KSEAGSAESK CIITEKIQQE APEFGKKLQN IKVRENETVE MSVSVKGIPE
PKVIFKKDDK EINIDNEHVF IREESENSYT LVINDARLED IGTYSCVATN IVGEAETSCS
FAVEKSINED DLVAEPMFVE PLKPCQVVEN ETAEMTCKVN EESKPEIQWF KDNKPIQLSD
HIIEEHLPDG SLKLKIINAT IEDVGEYKCE AVNKKGKAIT DADLNVKHGE VKVVDDNSGL
VEPMFIEPLK PCQVTEYETV ELSCRVNEES KPEIHWFKDN SPVKTSSHII EEHLPDGGLK
LRIESASIED AGEYKCEAKN IKGKATTDSQ LKVQYAQEKS SDDDSLMVEP LFIEPLKTCQ
VNENETIEMT CRINEESKPE IKWFKDNKPI KTSEHIIEEH LPDGSLKLRI MNATIEDMGE
YKCEAVNSRG KAITDAELDV KHAKEEVLNL DDLLAEPMFL EPLKPCQVVE NETAEMTCKV
NEESKPEIQW FKDNKPIQLS DHIIEEHLPD GSLKLKIINA TIEDIGEYKC EAVNKKGKAI
TDADLNVKHA EIKVLDDDSG LAEPMFLEPL KPCQVVENET AEMTCKVNEE SKPEIQWFKD
NKPIQLSDHI IEEHLPDGSL KLKIINATIE DIGEYKCEAV NKKGKAITDA DLNVKHAEIK
VLDDDSGLAE PMFLEPLKPC QVVENETAEM TCKVNEESKP EIQWFKDNKP IQLSDHIIEE
HLPDGSLKLK IINATIEDIG EYKCEAVNKK GKAITDADLN VKHAEIKVLD DDSGLAEPMF
LEPLKPCQIT EHDTVELSCK INEESKPEIH WFKDNIPVET NDHITEEHLP DGGLKLKIEN
ATIEDTGEYK CEAVNRKGKA ITDAELNVKH AEEKVIDDDL GLVEPMFIEP LQEQSVIPGD
TIELCCRINE DSKASIQWLK DNVPITLGPN IKEEKLSNGL LKLIISNASA EDAGVYKCEA
VNKKGKAITD SKLELKYATV QSVDEEEEVL EEMGDLESGN EERAKVADNR GPPEFVELIR
SCTTEPGADA ILTCKVKGEP RPEISWTKDG VKLVESDRIK IEHAKDNSIK LTIFNATLQD
SGEYRCDATN ELGAAWSEGP ILVTTEKIVD GEAPDFLQPI RPVTVVEGEK AVLEGKLIGK
PKPTVKWYKN GAEISPSDNR IKIEDLEDGT QRLTINQTIM SDNDEYRCEA TNEYGDVWAD
ATLKVTPKDT LCGFKKGLED QKLDLGADLI LNIEVDGKPK TVKFYKDGKE LGDAEDLGNG
KYSFVIENLK NEDFGEYSVR VFNDAGTVES TAKISVNEIE VPVISQGLIP VSAKEGDDAK
FIVEVKGKVD SIEWKHNGNT GVGKDLGNGK YEFTIPNVKK EDAGDISVTV KNSGGSADDS
TKLTVKGEPI SFKKGLEDKE AKKGDKVLLD IETSKKPKQV KFYKNGNEIP SKDLGNNKYA
IDIPSVDKDD DGVYTVKITD DDGNEVESSC KLTVKIPAEK PLFVAGLVPV TAKEGDEVKF
VIEVKGEVDS IEWKHNGKSV GAGKDLGNGK YELTIPNVKK EDAGDISVTV KNSGGSADDS
TKLTVKGEPI SFKKGLQDKE AKKGDKVLLD IETSKKPKQV RFYKNGNEIP SKDLGNNKYG
VDIPSVDKDD DATFTVKVTD DDDNEIESSC KLTVKLPAEK PLFVTGLVPV SAKEGDEVKF
IIEVKGDVDS IEWKHNNKSV GAGKDLGNGK YEFTIPNVKK EDAGDISVTV KNSGGSADDS
TKLTVKGEPI SFKKGLQDKE AKKGDKVLLD IETSKKPKQV KFYKNGNEVK SKDLGNNKFA
VEIPSAEKDD DATFTVKVKD DDDNEIESSC KLTVKLPAEK PLFVTGLVPV SAKEGDDVKF
VIEVKGEVDS IEWKHNGKSV GAGKDLGNGK YELTIPNVKK EDAGDISVSV KNSGGSADDA
TKLSVKGEPI TLKKGLEDKE AKKGDKVLLD IETSKKPKQV KFYKNGNEIP SKKISDTKYG
IEIPYADKDD EASYTVKIKD DDDNELDSSC KLTVKLPSEP IKIVKGLEDL YVPESSPINL
EVKTSGKPKT VKWYKNGQEV SDNIKTIDDN TFTYTIPSSK IDDSGLYEVE FANAEMTIKT
KGQVTVEREP KFTKGLEDKT VKEGEEVIFE AQTTEKVRIV KWYKNGKQIS ETKRIQIVSS
ENSYKLIIKE TEMEDFGEYK IVLENSAGKI ESEAKLKVLS GSDVEPMIVK GLVPATVEVG
DEHSFRVEVS APVRTVKWYK NGQEIQPCKD ISMKKINPKK YELTIKEAII EDIGEWKVVL
SNDAGECDSS ANLDVTTPEI VKIFEGLKDQ DINEGEPLEL KAKISGKPRQ VRWYKNGQEV
SPSADIKISD VDGEYTFTIP SSKPEDAGIY RVVFTHDKGE IPSSCSVYVK PKRKEEEGKP
ADFLGPLTDV TIPEGETLTL KCQIYGVPMP ELTWFKDGKE LQKSDRIAMR LSLDGTASLR
ILDAIKDDAG KYTVVAKNKH GEKESSCKAN VLDESEIPGP PRFIIPLKTT DSKIGEKVEF
SVKVRGFPKP TVKFILNGLE VIPNDNYLIE DLSNGHWMFT IKSVEHEDFG SIRAVAKNEH
GEVQCNASFC ESMSRTFKPR DEEGYEPRWN VPLWDRRLPE GHPAAIECHV DAKPKAEITW
FFEDQVITKE TKGIEFINTP DGCCKLKVLH LTQEWVGMFK CVARNSYGVA DTRANLNIEE
EHYEELEYKR EYPPRFNPQL NDAILEIGKS VTLETTVDAI PMASIAWYKD GLPIKATSNM
KIDFDEYSGR CTLTLRDITE ADTGAYRCIA TNVHGTTNTA CLVGIRTPKV EIIKDGEEPF
FTKGLTDKWV DRGGELSMTC TVTGSPFPEI KFYRNGILLR SNNKTKVEIL PDGICNLTVY
DCTLSDEGIY RCEAENKYGK AKTQSTVHVE VSLKNLDRNI KEEGEAPRFV IPLEDNVVSP
DGIIELNCKV TGKPTPLIKW SKDGAPLFDD SRFEWDNNPT GGTYSLKIRN AKNSDEGTYR
CIATNDEGSA NTKAFIRIDD MGLSRKPTKS ESVQPPRIIM NIGDARANEG SPLKLTCKIE
AASPLDVVWY RNGEKVISND AYQVSLNPDG TAVLYIPKCT MDDDGIYRVI ASNPYGTAQS
KGNAVVRRGL EHSDSFRRSP FRSPSTSSFD TGKAPKVVIP LDNIKITDKQ SFKLRCKFVG
ERMQIRWFKD GERIYSFGRT QIFENIDGNA ELEVISAGRF DAGCYRCVAE NEYGSARTTC
DVIIEAKGRK TSRDYSSDSS SGNAPGFITP LTIKRVKFGE SVTFECLPYG KPFPDIKWLK
DGIELSNNNG IVIESETEGI QRLIISSAKF ESEGYYRCN
//