ID A0A0N4ZPE4_PARTI Unreviewed; 359 AA.
AC A0A0N4ZPE4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
OS Parastrongyloides trichosuri (Possum-specific nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Parastrongyloides.
OX NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0001040400.1};
RN [1] {ECO:0000313|WBParaSite:PTRK_0001040400.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR AlphaFoldDB; A0A0N4ZPE4; -.
DR STRING; 131310.A0A0N4ZPE4; -.
DR WBParaSite; PTRK_0001040400.1; PTRK_0001040400.1; PTRK_0001040400.
DR Proteomes; UP000038045; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 6.10.140.250; -; 1.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 2..125
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 118..282
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 288..358
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..106
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 42626 MW; CBD0271F7EE78DD6 CRC64;
MPIDYSKWGK IEVSDDEDDT HPNIDTPSLF RWRHQARMEK MAENEKKKKD LENQKKDINN
HISELKEKLE STTINDEERN DYQKKLDNFL KQLNDFKEKE KQFEEMLAKQ PWNVDTISSE
KFSKSRINKK KDEYKPKTPE DAYENMQNVL EQHKASIEKY KKCNGISEIS NCLRTYPEIV
CEEVANYLTI EALNHAIMEE ENDLVRVATN VQYMQYIIQL SNELKIPPNT YVMVNRFFDK
VMQNNETFKK DHTIQLDEFL SKLRHRGKVK RDEALKEIEA EEKAERIKNS PKGIDPLEVL
ESLPEEMRLC FEERNIEKLQ QVATTMDPQV FKYHFQRCKD SGLWVAGDDE GEAEEKEEK
//
