ID   A0A0N5A1U7_PARTI        Unreviewed;       700 AA.
AC   A0A0N5A1U7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=Protoheme IX farnesyltransferase, mitochondrial {ECO:0000256|ARBA:ARBA00016335};
DE   AltName: Full=Heme O synthase {ECO:0000256|ARBA:ARBA00030253};
OS   Parastrongyloides trichosuri (Possum-specific nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Parastrongyloides.
OX   NCBI_TaxID=131310 {ECO:0000313|Proteomes:UP000038045, ECO:0000313|WBParaSite:PTRK_0001559400.1};
RN   [1] {ECO:0000313|WBParaSite:PTRK_0001559400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O.
CC       {ECO:0000256|ARBA:ARBA00004013}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004225}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005985}.
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DR   AlphaFoldDB; A0A0N5A1U7; -.
DR   STRING; 131310.A0A0N5A1U7; -.
DR   WBParaSite; PTRK_0001559400.1; PTRK_0001559400.1; PTRK_0001559400.
DR   Proteomes; UP000038045; Unplaced.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   Gene3D; 1.10.357.140; UbiA prenyltransferase; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR005331; Sulfotransferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   InterPro; IPR044878; UbiA_sf.
DR   NCBIfam; TIGR01473; cyoE_ctaB; 1.
DR   PANTHER; PTHR43448; PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43448:SF2; PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF03567; Sulfotransfer_2; 1.
DR   Pfam; PF01040; UbiA; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        128..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   700 AA;  81651 MW;  9BD08D66378CBDC8 CRC64;
     MLSKHVMNQW NYHKSSIQIS LIIKNKINCT RFLSLQNTAP HPDEMVELKE KSHNDNVDKR
     KKDLFASTII KLDGNQRNDI RGNLLFPPLP IKINSKKKIT IQSRDIGNGW VKMNSGNLIK
     TYMDLSKFRL TMLIATSTVG GYFMAPVVYE PKTFLTCLVG TSLMSCSANA FNQMLESPYD
     SQMKRTQNRL LVTNKISPFH AFSFANICAL TGGSLLYFGC NPLTAFLGLL NIGLYAGIYT
     PMKRHHIGST WMGAIVGAIP PVMGYVAVSG QLDLAAFVLA AVQYSWQFPH FNGLSWNLRA
     DYSRAGYRVM CVTDEKLCRK TTLRHSLALL GICSIAAPLS GLTSYTFAID SLPLNIAMCY
     FGYKFYKTPD AKTSRNLFKY SLLYLPLIMI LMVISRQDNK DISLLFKYSK KGVNCNVPIY
     NISIDKYRNG KVFDNEMEKQ CIEAFNEFYP RYRITEKYKI NYCNIDKNFS TMMTAIICYL
     ENEKLFEKKH FKDEIFNRRS CGKKNEGTDI EEIKRKFMKN DKDWIFIAVI RDPLERFVSG
     FVDKCVINRE WLKDKRKCGG CRMDIKCFLE YLYDRMYRRS VNGERLNNFD DQHFFPQNWR
     CQFNKYMNKY EFIKYSSTKE GTKEFMKNLF KILKQKNISD SSINFIEKEI NYGRTYHSTF
     DTTDKEYFTN ILLKNKYLLD LFLRMYYYDY QLFSFTSPKI
//