ID   A0A0N5AN47_9BILA        Unreviewed;       508 AA.
AC   A0A0N5AN47;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=protein-histidine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00898};
DE            EC=2.1.1.85 {ECO:0000256|PROSITE-ProRule:PRU00898};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000602201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000602201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) +
CC         N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:19369, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:11600,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16367, ChEBI:CHEBI:29979,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.85;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU00898};
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. SETD3 actin-histidine methyltransferase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00898}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0N5AN47; -.
DR   STRING; 451379.A0A0N5AN47; -.
DR   WBParaSite; SMUV_0000602201-mRNA-1; SMUV_0000602201-mRNA-1; SMUV_0000602201.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0018064; F:protein-L-histidine N-tele-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd19176; SET_SETD3; 1.
DR   Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR   Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR025785; SETD3.
DR   InterPro; IPR044428; SETD3_SET.
DR   PANTHER; PTHR13271:SF47; ACTIN-HISTIDINE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR   SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51565; SAM_MT85_SETD3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00898};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00898};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00898}.
SQ   SEQUENCE   508 AA;  59062 MW;  BF289DBA0F2D7BC0 CRC64;
     MSSSSLVQRN EILQKLRNKC DYLWQSKLTQ SAPESPMNAL WEEHLEIRQQ LKEIFKLQEE
     LGAVVPKAND RQQSLIAFMN WCDRMKIKRN NVTVKYFDNI GFELQTTGEV KEGEDMVTVP
     RNALLSWDLA RKSVLLKKCF ERDIIVRSMD NVALALMLCC QKLSSDSFWH PYFNILPETF
     DTPLYYSENE LQALKPSPAF EDALLLFRDI TRQFLYFMIE VIHVVEYRSA KLQKKQQAQM
     HEPTFLNTPL TPENFTFDLY RWSVACVSTR INMIPSQDLR NHNDAPVLIP CLIPLLDMAN
     HEVCMNASLP HVYFSAENDC ASITAVRNYN AGETVRIYYG KRCSSDFLLH NGFVPESDSF
     EDTCKLKIGI TKKSEFYNAR LKMMQDYGYT TNSNIFHFDL SLKEPYVDES LLYFARVFVL
     NNPDENGKSQ LETYDVTLKA WDFLRKRLEL TLSTYGKLDN IKPATSREAT ILRLKRNEVK
     VLRKAFHYSS EQYLKLLSQS QQEGQVAA
//