ID   A0A0N5AW49_9BILA        Unreviewed;       922 AA.
AC   A0A0N5AW49;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Rap guanine nucleotide exchange factor 4-like {ECO:0000313|WBParaSite:SMUV_0000913501-mRNA-1};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000913501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000913501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC       {ECO:0000256|ARBA:ARBA00010829}.
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DR   AlphaFoldDB; A0A0N5AW49; -.
DR   STRING; 451379.A0A0N5AW49; -.
DR   WBParaSite; SMUV_0000913501-mRNA-1; SMUV_0000913501-mRNA-1; SMUV_0000913501.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.8.1240; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          149..243
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          318..398
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          455..596
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          638..716
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          740..922
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   922 AA;  104625 MW;  EA93888B56933A18 CRC64;
     MFHLTSYAVL QNLEDLTVES LNSVSLFGEL SVFYHTCSAR ITKPTELVLI NQNHFIALYN
     KYADHLQPYL TILQDLISAS GEMANFEFGE MQKEVRGMAE DEMKTSGEVA SRSHDYDIAN
     CDAGSDVCCE QPSSLFELRN TTSLEIRINE AGLILKRTIQ ARAPGLIQDR KGHNQMCLTC
     MVGTEMVDWL HNFAVETLHS TTLSLTRLHV IGMWQALLEY GIISHVKSEQ QFSDKHVFYR
     WTNDEAELHL ATKMNGDLEL IEGDVPKTPY ISDIASAIFF LSTVGPDALF RMILEKPPLE
     RTVEDLEVVY EELLNVKALA HLSTMVKREL AAVIRYEQHQ HAGTVLFRQG DPGNCWYIIL
     KGSVNVCIHN KGTVCVLQEG DDFGKLALVN DAPRAATISL REDNAQILRD VEANTVRLKE
     HGQDVLVLEK LNSKYKHRLY ADSFIGEPSV QEHQCCYSVM AGVPEKIVDY LLETRVDAQE
     NDGGVDTVLE DFLLTHSIYI PPNVLCKYLK NYYMQRSVTG SVANTDISFN DATRLVATKH
     RVVTFLELWI NTLGLHFFLN PATNSFVEEL FCCVLEDSKC LEGMQEIFQK MLEIRQFREN
     AMQTLNRHPT VVLEQSIYTV DAPAPNPILP FDTCEQVIYV LNSASISLSI RLDKTAADVC
     ELAKAKLHYG GPNEEFQLVE VKSSGERIVM SPTEVGIPTM LFLNSRLYFT YADDDSHLPP
     MPRQYEPDPA YYYSVLENLS SIEIAHQLFI FHMHLFEATS EVELVTQVFG RNQFPGWIPA
     NLDLLLRRFN EVQFWATTEV LLAQGPSRRL GILKKLIKTA AYAKENRDLM SLFAITLGLS
     NIAVSRLTQL WNKLPAKPRR QYAEFEALLD PSRNHRAYRM LVAKMIPPTI PFVPLILKDL
     TFIHEGNKTF FGDLVNFEKM VS
//