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Database: UniProt
Entry: A0A0N5B3W8_STREA
LinkDB: A0A0N5B3W8_STREA
Original site: A0A0N5B3W8_STREA 
ID   A0A0N5B3W8_STREA        Unreviewed;       316 AA.
AC   A0A0N5B3W8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   13-FEB-2019, entry version 11.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000076800.1};
RN   [1] {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000076800.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SPAL_0000076800.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   WBParaSite; SPAL_0000076800.1; SPAL_0000076800.1; SPAL_0000076800.
DR   Proteomes; UP000046392; Genome Assembly.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000046392};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046392}.
FT   ACT_SITE    104    104       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID     12    309       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    182    194       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   316 AA;  37616 MW;  2962AEDC4D7528E3 CRC64;
     MEILWNLPSQ HCQKYEKTKI SLADYNIKTN EKYTFRGDKI IILYENEVGL YPHIKNHTNG
     TIEYINNGLP QSVNMTKHLK KLEENIKTII KDENFSGLAI IDIEEWRPTY DSNWSSKRIY
     REQSIKQVLD KDENKNLDKK EAEKIAIEEF DKAAIKFFNE TLHKCKQLRK NAKWGFYGFP
     TCNENAKDRN WSFCFPNISD KTIPIFQHVD VMYPAPYIVK GQNYSIKNLF VQAVLNETKR
     IVNKISEDGE KKKPIYVYQK FEVNPFVEKI KDIEFYDPYY LCITYKNMIY YKVDGIIVWS
     TSRNMTDRCP YIKNYT
//
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