ID A0A0N5B4T4_STREA Unreviewed; 1579 AA.
AC A0A0N5B4T4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000108300.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0000108300.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR STRING; 174720.A0A0N5B4T4; -.
DR WBParaSite; SPAL_0000108300.1; SPAL_0000108300.1; SPAL_0000108300.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 953..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 686..789
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1195..1457
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1372..1448
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1001..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1579 AA; 179172 MW; ED248778EE914A6C CRC64;
MKKYLLFSKI KLLLIFVISY LFFYLAKCNS VEQQTPFNVN NNQNNAIINS QTNERIPENL
INHASISTIL NEFSKQFTIK KDDSDPSRLL NVLLPTNFLN YHQFIAKVTD ISPSVDFPLR
DVNRTFLAFP SDSSIINIHG LHAGHKYDIA IYGRIVNETH LIKKETIFMD PVPLNFHDNA
SIIVMHTNIT MRALKPERAL QDTFRVEYIQ LSPPKRYPIL DVHDIPEQKY VDFYLGNLNP
GRDYDVKVTS IRADIPSQPW QGVITTKPLQ VANITVTDSV DSNDSNCVHL SWMLPIQSGA
DKFKILYGPT TAVESGMHSL EVEYTKNAVK ICDFIIPGVD FLFIVSAEKS NQLSDPQKTT
FTVKPQAPIN LSLQPNIDKG LYKLTIYLNN SSKSKADSCK YSIIDDNSNK MEGEMTTEVI
DGTLSCNTYL NLIPGKRYEV SANTFSNKKG SIKILRNMAL APGFDMKYFD LSLIENNGII
TIKWPRNEVK LRRLVDIWSR IIGNGSTLQV KIESSSDGKI IRNYSTNPST AKDIIIPNLI
RGACYNIEIY TLTENGIVSN DKYEKNIRIS MTAYDINTEN ISKTSTIVTF NETGKIGEWY
ENSVDCKLAI LINDIHGNNI YDKVFNMQKA DEMIFSKIIL NNLKSYTKYA VNSQITCGKA
DDKMCPQSTR TMNMITFETE QDVPGYIKNL TIKPLNSYSC HVSWKPPTEP NGFITRYLII
INPDKSNLIG EVPWTLTVNG NFDSNNKKID SIVDNLVGGQ KYSITVLAVT VAGTSSVSNT
DNTIHIQMPI GAPPKPSTTV EVIQNTIRSS DLSIRYNMRM LSSKNGPITK IGIIVAEVDP
KTEMPREPPS HNVLSSPSSS YTWYKVQNYE ISPPYITSIT NLKPQKNWGT KSISEVIGIE
PNCESKDPDT ICNGPLKANT MYRFKLRMYT ADNLWTDTNY SDIAKTDLLK SGFMFRTILL
FILLALCIAI AIILLICINN CRMSKKNNEK KRPVLFGGCS SSNSNGSSSL GIDRNYGSSS
KNSTSSSSEV SPNHRQNQWT AFKMLIRNRT AEIVNKFSLD QSSFTNHHTS KDTNNTTSNC
INTNSQRLPN SSRISMFENI EDNNNKTPIS SPIIISHTNG QMVNSSIVRP INNSTKTLKQ
RTGFDKRLEN IGTVPPKIIL QTVMKVDNPS RNRPVKIEDF LEHVRLMSAD SDFRFSEEYE
ELRNIGITQP CIASELPINR AKNRFTNILP YDHSRVKLIS SDDDDGSDYI NANYIPGFNS
RREFIAAQGP LPSTRDHFWQ MVWEQQVPFI VALTKCVEKG RDKCHQYWPD QDQLSVLYND
IEVTLAKETM YDDYVLRELH LTNMSYDNLP KKVVYHLHYK AWPDFGVPNH PGGILHIVRL
FRSKVPPSKN CRPSIIHCSA GVGRSGTFIA IDRLLQCMAI NQPLDVFGIV HEMRLERCQM
VQNEQQYVFI HLCIAHAIEQ EMLKKQNYMN MMSINQLPQQ NINQNQLLNG IPNTNIQYSQ
DYDSQYSSPQ RYNGMLVDQH LPYATQRTMN TSLQEPSNIW INPYQQGQPI EGYHTIDIRE
FHQNPIFIEE DEGIAESGL
//