ID   A0A0N5B5H1_STREA        Unreviewed;       804 AA.
AC   A0A0N5B5H1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000131300.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000131300.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A0N5B5H1; -.
DR   STRING; 174720.A0A0N5B5H1; -.
DR   WBParaSite; SPAL_0000131300.1; SPAL_0000131300.1; SPAL_0000131300.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd18788; SF2_C_XPD; 1.
DR   Gene3D; 1.10.275.40; -; 1.
DR   Gene3D; 1.10.30.20; Bacterial XPD DNA helicase, FeS cluster domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR045028; DinG/Rad3-like.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR006554; Helicase-like_DEXD_c2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR   InterPro; IPR042493; XPD_DNA_FeS.
DR   PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR   PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR   Pfam; PF06733; DEAD_2; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   SMART; SM00488; DEXDc2; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          37..347
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51193"
SQ   SEQUENCE   804 AA;  91371 MW;  7F479F8F27B04A08 CRC64;
     MLKIVPCKDN DVIPKKRSRI SIGIQDDECK GIEIGGVTVQ FPGQFDPYPS QTSIMEAIIT
     SLDNSSNALI ESPTGSGKTM ALLSSSIGWL KSYKNKIKLS KMNCKLHSNE NNKENKLNND
     ESFDDNDNLK NEGGSLCQCT CMNSVKIFYA TRTHKQIAQV IKELKRLPYC YAQDSENIHH
     TILSAKEQSC INLDVRKLKN INQKCRRINA DEKSRCIFKT NFNRCFDDSN ITTLNDILPV
     WDIEELNEYG TTNHICPHFA ALKLFRNGAD IVFCPFNYII DPKIRDRMGI DLENSIVILD
     EAHNIENFSR SSSSFNFTED EIVKSLDDVR IRRNSLKKLL GGDSPMDIMI EEYNIGNTRP
     NEQEIAYLTG CLPQMEYLLE FMNKLFEWFQ NFAPEVLKEP IKMDVFTSKL LVYKTDPLEL
     EKLKGALTCC STIGYGENSV ICSSTNGLDE WQEGDESYSE VTEGDFIGDR KCEKLKENCV
     VKLELWCLDP SLGFKDAFNN VRSIILASGT LSPIDTFISE LGLKFESIVQ GDQIIPKEQI
     FASVIGVGPN KKDIICTKNK ISAGEQKNGN SVLFEIASLI VDVCENVKKG VLVFFPSYSM
     LEQVFQKIST SQLMAKLEKV KVVLREPRNS NSNSLNNVLM KYEKAIKQPE SKSKSCTGSV
     IFAVYRGKFS EGIDFADDLA RCVISIGIPL PNIGDPQVIE KKQFNNKFRV KKNLLPGDEW
     YKIDGYRALN QALGRCLRHR DDWGIIIMVD KRLREDIEYN SLDKYKISKW VVDNIKSYRS
     YEAFRKQMIT FANAREKLSV PVKK
//