ID A0A0N5B6R1_STREA Unreviewed; 533 AA.
AC A0A0N5B6R1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:SPAL_0000174800.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000174800.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0000174800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR AlphaFoldDB; A0A0N5B6R1; -.
DR STRING; 174720.A0A0N5B6R1; -.
DR WBParaSite; SPAL_0000174800.1; SPAL_0000174800.1; SPAL_0000174800.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF415; ACETYLCHOLINE RECEPTOR-RELATED; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 20..533
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022264757"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 287..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 321..342
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 44..251
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 258..513
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 533 AA; 62828 MW; 40E6AAC7884B5855 CRC64;
MRLYFILLLT INITSNIYSN NLKLNQFSNE YIERRSNLPY LQILHRDLFH DYIPDVRPVH
NDSLPTEVTV QFWLKQLLKV NERDQTIRLY LWLELYWKDE ILTWNPTKYG NITEIHVPAN
KIWSPDLVVY NSANMNVEES DMEKNVVIKY DGNVVLFRST ITDITCNLNL ADFPFDNQIC
YVTLASWSMD GSKIQLKAID RNTNNSYLEL YIQHSMWRML GMKHKTFIKY YDCCVNPFPD
ITYFFVLQRS PSYYIFSLII PSTFITVVTI IGFFTPHSTT GENTEKVSLG VTALLSMAII
MMMVSDEVPA TSDVVPLIGK YYIGLIGLIF SAAFSTTVTL HFQLRANIGI RMSEQLRKLL
FIKVARNRIF QFFFTLQMRK RSAREMKNNA LLFGLHTANI MFNSHLIKTN LTQAFLKRDS
LLEECHAEFT NREEQVWKLK EDVKLLERED IFDIRMRKVF YKILNHISDI SFIMKHEQEK
RIIITEWQQA ARILERLLML FFLFATALFH IVMLTSPYND IILTDELLEK IKK
//
