ID   A0A0N5BC47_STREA        Unreviewed;       740 AA.
AC   A0A0N5BC47;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Acid-sensing ion channel 1 {ECO:0000313|WBParaSite:SPAL_0000359600.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000359600.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000359600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A0N5BC47; -.
DR   STRING; 174720.A0A0N5BC47; -.
DR   WBParaSite; SPAL_0000359600.1; SPAL_0000359600.1; SPAL_0000359600.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF273; DEGENERIN LINKED TO MECHANOSENSATION; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        125..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          597..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  85160 MW;  F5062D89E4AC52B7 CRC64;
     MSIFKKSNNV SDRSKPKSLV VDRPRVVIQR PSVDGSDSII NVDLEDQKSE KDDKRRKSKD
     SAIELFDDYR KTFRSRASQM FIDFPTQHLR KFAKTKPMSS VRREVAFFSG ITSIHSVVRI
     YRAKGIYKIL WIAACITSLT LLILQCKSVI KTYYSKPTVS QVSFIIPEGG LEFPTITICS
     YNPVKRSYVQ ELNSTGLFSK ELLDYLTLAY LQITQMFTIG DYDRLIEGDT HYQIYRREVN
     NNFSINGFFR EASFSCEEIF KVCSFAGKEF DCCSEVKETL TDMGKCFRID LKSSKKDWVR
     KQKQSGASSG LMIIADFLKD EQMGYGKQIS EESIFANEFE TGFRYYIHTD QTIPYLNTEG
     ISVSPGIRSY SAIESNKIEL LNTDDWGNCI GGWPSGYEND ISYTAPNCKA RCRAKYFNKK
     CGCSPFVFNI GGIYPVCTPF QVYQCLAEEY EQEIVNIKLR ELIPTPEIDI ELPICPECKQ
     ECDSWKYFTY NSYGQEFSIG ALSWLNSRNK NWTAKWVVEN FVAINIFYRD MTYTVYTQVQ
     STSFVQTISN IGGNAGLFMG ISFISCCEFS VFLWKLFWAI VSKNRQNYIE KKNTKEKLEN
     KKSTNSNETL NESQPHGIRE NAKKQIKQIG SYLTNGLISS KNSSHHLPIY CERFSATPQE
     SRVRGSSYID NVVANNLNGL GRAEDFIDVE PALYDIKRFS SFYDHERARS IVKGRERQRL
     RSLSYNDSPD YKKNDKSFVF
//