ID A0A0N5BCL2_STREA Unreviewed; 1147 AA.
AC A0A0N5BCL2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000375800.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0000375800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A0N5BCL2; -.
DR STRING; 174720.A0A0N5BCL2; -.
DR WBParaSite; SPAL_0000375800.1; SPAL_0000375800.1; SPAL_0000375800.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..211
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 336..447
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 698..972
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1147 AA; 131257 MW; 8B4FAF013B36A698 CRC64;
MKTTIYFWRC TTLLYFLIYL TNSAKVLLHD SYVYKEELPY EYFSEGDKLN DGIDDHPNWE
QESYYDEDKN PIVVSTVCNE GKKPSYIKNW IALPKIEKGP AKKLHLEISY SINNCSQSKP
YCKEFFDVFY MPLNGGDNGK NKLRNKDNWM HLKNLNLHSA KITKGDQDFI VATIDYIPLS
DGVIFGIREE NTCSSILRIR IYYKVCPSQT LNQFQLPETV VGVDLYVPTF YHAGCVTNAI
MLDSKSTPRN AFCKANGEWE LLNDNTCQCI AGYSPNDSGS CSPCTKGSYK STVGNGICKA
CPRNSHSYDN GTHICECDID FYRADNEDPS HQCSQPPSSP VNVRALELKS SEATIIWSNP
TYMGHRSDIY YSISCEFCDE SKHCVKCSKS VTNSFDPERI EGKQITLKNL EPGRDYIINV
FAHNAVSKKA AGNLHNKAIF TFTTAKPFNF KMNTPKLLSH LNNGTLLISW EPYESEKYYK
GEENMYYQIE IRNDKDILLM DSIQTALKIE NIDIYKSHII KIRVHDPKKG WSQWSDELMV
KNKYNKGGKF SNQQFERIPN DMVIGTGTEK TDTSLYMSIT QLYSQNPRIF YIIGCLIVVL
LILLNIFYFC HSKKNKKGDY FAELVKSQQS DIPYNLNMTP SHLYYGKQFD SQFLNGFGSA
TTFVDASVNK TYVDPSTYGD LSVAVKEFTK QIPKSNIFLT GEILGGGEFG DVQKGILHLT
GSMKSRNTAE GGELVVAVKT LKKCVTEQEK KYFTMEATTM SQFYHENVLR CIGVVGTNYV
EMIVTEYMIN GSLINFLKSI SPETYSKIKL AHMCLDVAEG MSYLHMKGYI HRDLASRNIL
LDQFYRCKIA DFGLSRNGFN DENVELEYTN AMAKKIPIRW TSPEALEKGL YTAASDVWSF
GILMWEIFTF GERPYYDWSH RKIYEEVIQG YRLPKPDDAP EALYRVMVQC WNQDRNERPT
FVAITNEIKS YIRIYEDNRD YIANSPLYQC PSDVNYDVAR DGSSNNNRMS HNNYFFTSRP
SVSQISINAS AHRMSNWDIA RNSLGDLERQ ELENALAKFN IQYLIHHLYR MKIFSVAQLA
NLPLARLADM DITLNEQKQL AVVMDHIVTS RRAVTNVSRN LMSNQAPIVP QFSKTLNKES
IDGGFLV
//
