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Database: UniProt
Entry: A0A0N5BIP6_STREA
LinkDB: A0A0N5BIP6_STREA
Original site: A0A0N5BIP6_STREA 
ID   A0A0N5BIP6_STREA        Unreviewed;      1453 AA.
AC   A0A0N5BIP6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000582600.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000582600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   STRING; 174720.A0A0N5BIP6; -.
DR   WBParaSite; SPAL_0000582600.1; SPAL_0000582600.1; SPAL_0000582600.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProt.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          305..319
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          522..776
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          1143..1305
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          1364..1385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1453 AA;  168348 MW;  F6A8200899D3BCA6 CRC64;
     MPSKEEKLKS VLSAANELGL NISNEVVPGK KLSVINLLLR GYSDKPEELV ENIRLIVADI
     KRLLKTTTVL VKKPKAEEKT EKMARYDLSL YKTLPVFEGE SSFVNFYEQF KDAMEFAVDD
     EDEEELHPVP EKKQLVLLKG KLGEKVQERL RTIDKDSNLT QITEFLKECY AKYEVSKDKL
     RIHINRMSRD DFKNYEEYLK ELFKLCEKYH MKEEKEVRDK LIIADIICKH DAQTQRAVEN
     CGIKNPDDLV EFLKLREKRD GKFDNVRNKK GFSSKSFNQS KTEVKGTKFK MHQETPVNKK
     DNIICYACQS KGHYASECKT KGDSLEKVSR IETERKVNVV KKDKMKKFDR CPRSVSERCN
     NDLIINVKLG KKSKEVERIC MVKGLIDTGS TVTIISEKEA RYLGYDDNVC KDEGTSFVLA
     NGAKWKAEGT MMLEICIEDV KIYNQVSIVK EEEICTNGKY NMIIGNDTLM AEGANINYAT
     KEITFLGRLV NANCDSNVKA EGLMNRVSTV RREGTPCVFE LKEKMKSAFP EVISDSKVDI
     GCCKLSAPKL QVLKQFPKAY RYKHSVKDKE IIKETIEQWL QIGAIKKCYN PSVIINLTVA
     VRFDTTEVVM KNDKLEDEVQ IQVKRDTRNL KDEYGRLCKG RYFSKIDLRQ FFLQIPLNEE
     DKTLLGIQCP VTNELYSWQR LPFGLNVSSS IAQSIINEVI ENCEFKDENG AVIDENLYGV
     MAYIDDILIY TMEDSMQFHK TILFCMLKGL CNYGLKINAG KMELMRTEIC YLNVILSHMK
     IRPNPMYIKG LLKMKKPSNV SELRRYLGAV NYCRDFIFGI TELEKPLLTL LQKDQSYLWT
     DECERSYNEI QTMLKEVGFL KLPDQSREFI LFVDASKYSE SGLLMQMAKV NEIEKLWIEK
     ESKRYPDKYK GIVEDLKENQ SSINEDEERL LPVGYYSKKL GMGESASATL LEVRGLCRTL
     DHFKEVTKTS KVIAYTDHKP ILQMLKGGKP ESGRYIRYIN RIFQYDGLRI RYLEGAKNIA
     ADYMSRAYCR ATRRKLIRVK EKGNEILVKD GNNPAEEGGG CTESQLNDEI QGKEEMEEKK
     LLLFKEIHDQ QGHPYAEASI DMLEKRWPYE NIKREYRNYV NNCKICIERN GIHKTMMKMG
     EFTADRPLQM VQMDCLGPLP TSERGYKHLL VWIDVNTRFV GGWPIPDLSH EKIVEAVEES
     LIYRYGMVEN VKADNSKYFD KALEVLKERY KIGVERGVPY KHTSQSLVER VIQTLQNVIS
     KTGMELLINL EAQWDKVVQR GFYAINNMKH ATLRESPYFL MFGRRPLLSW DLEEMEDMDA
     TEREGRISYL VDQQTEFEHQ LCNRYSALLM KAVRSKMNQM IMENKKKEKS AVEKSHYTPE
     QTPRDRLNIK VGDPVAVFFP KKNKFEACWK TGYIVVNITN DEGESLKIYC KKKNKTKGRP
     LVRSINDVKL LNL
//
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