ID   A0A0N5BN39_STREA        Unreviewed;       135 AA.
AC   A0A0N5BN39;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Gamma-secretase subunit PEN-2 {ECO:0000256|ARBA:ARBA00018306};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000731800.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000731800.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PEN-2 family.
CC       {ECO:0000256|ARBA:ARBA00009607}.
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DR   AlphaFoldDB; A0A0N5BN39; -.
DR   STRING; 174720.A0A0N5BN39; -.
DR   WBParaSite; SPAL_0000731800.1; SPAL_0000731800.1; SPAL_0000731800.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR019379; Gamma_Secretase_Asp_P_PEN2.
DR   PANTHER; PTHR16318; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR   PANTHER; PTHR16318:SF0; GAMMA-SECRETASE SUBUNIT PEN-2; 1.
DR   Pfam; PF10251; PEN-2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   135 AA;  16024 MW;  176CBD4657CB28DD CRC64;
     MTNTRNNQGN ENVRSRGHHS GENTIERVVH AANIHPEHSH KSMDKKLDEC KKYFKFGFFL
     LPCIWLIVVI TLFHEYRNKN SQYEKKEEVK KYFQWSLIGC GVYVIIFIGW LSFYINAYRN
     DADWAYKIGA IYAIK
//