ID   A0A0N5BNB8_STREA        Unreviewed;       974 AA.
AC   A0A0N5BNB8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE   AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000739700.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000739700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365006}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC       {ECO:0000256|RuleBase:RU365006}.
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DR   AlphaFoldDB; A0A0N5BNB8; -.
DR   STRING; 174720.A0A0N5BNB8; -.
DR   WBParaSite; SPAL_0000739700.1; SPAL_0000739700.1; SPAL_0000739700.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR   CDD; cd16293; CPSF2-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027075; CPSF2.
DR   InterPro; IPR025069; Cpsf2_C.
DR   InterPro; IPR035639; CPSF2_MBL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   Pfam; PF13299; CPSF100_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|RuleBase:RU365006};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW   RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT   DOMAIN          289..454
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
FT   REGION          509..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          671..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        673..688
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   974 AA;  110042 MW;  A17488B8230846B9 CRC64;
     MSSSVKFTTL NDDPYGSYQA YILEIPPYTF LLDCGWDSKF NMTYFNSIAA YADKISAILI
     SYPSISHLGA LPYLYSKCNI SNVPIYCTFP TVKLGILTLY DWIASLKQNS EFNLFDLEDV
     DRVMEKVQKI KYSQLITINT LKGVNCQQFQ ISDNYNKTDG DIEIPLEKQV TIQALCSGHM
     LGGSYWKISR MSDEDIIYAV DFNNKKERHL NGANFNAFIN TNVSNPSSST LSSATNIGTK
     PLLFITSGVN AGYIPEKRRT RDEKFLSSSY ETLRNGGDVL VCVDTGGRML ELVNLLNSAW
     SNNNIAINNN ANQDDARDTN ITNQYRYNFE PYALVILSNV GNSVLQTAVM NVEWMNDRFT
     VDHTSSSILG NGTTEGINGT SMPTVSAFSY DNFNICNSLE ALDAIPQNKL ILVPSFDMEI
     GFSRNLFYSF VEDPKNLVIL TNRSGDRNSL AGKLFRIVEG RNKEERGLGR SEETIDLDVK
     LRVLLEGKEL EAYNQRKLDA EAEEARKKQE EIRRNQQLRE DEEQEEERNV LGMGKTETCG
     GDEIENSEDF LSIDNIFKQN LPKGFKMELV DEEFNTTING ESKKLANKTL DYSSLEMEVD
     VTKTEGEEDD DEDDYSSLIF PLGERNSEHE MMSYLPLKSY DQPWDDYGEV INPEEIIALD
     PYRKAFASKE GVLENDDDDD ENDTHSVDDE MNDDLGGGSK KQRLAGMKLT KESLFPWTAA
     PTKCISCNQT FHLNCQLTFI DFEGRVDGDS LEKIISQMSP KNLIIVNGYD QAVHKLMTLC
     RDTVKIEGIV ENVKVGKGVE IIGDNKGKVV KMSKDLISRT NMIKIMNGQE WSWVEGVLES
     KSVKDGDYHM SDIDDNNVTD DKENIEKDQE MNDITESENE SIAKNNESQL ILKPCTVTTS
     KPHPVLYLNS PKLIDIKARF TAEGYNAVLY LNILHINGIA TIQKDDTGSV KIEGKYCMEY
     FKIRDLLYNM FAII
//