ID   A0A0N5BT06_STREA        Unreviewed;       180 AA.
AC   A0A0N5BT06;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   14-DEC-2022, entry version 20.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|RuleBase:RU364141};
DE   AltName: Full=Mediator complex subunit 4 {ECO:0000256|RuleBase:RU364141};
GN   Name=MED4 {ECO:0000256|RuleBase:RU364141};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000900000.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000900000.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364141}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
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DR   AlphaFoldDB; A0A0N5BT06; -.
DR   WBParaSite; SPAL_0000900000.1; SPAL_0000900000.1; SPAL_0000900000.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019258; Mediator_Med4.
DR   Pfam; PF10018; Med4; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364141};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364141};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364141}.
SQ   SEQUENCE   180 AA;  20740 MW;  B0242CEAD1FA726D CRC64;
     MSRFDDNTLS LRESFEENYN DIEAIVKMML NNLNSSDMGQ RLVREDVNFL DLAKLLHLKE
     NEFEELMEKV GEFQKREAFI RKLEKEVLFY DTILSNIEIT LRNNVSSLLE IKEKAQTKLE
     RIEEISEIPL DVEECVSVSK SIAKSFGINN NHTWVPGSED RPYPTAAMLL NSTFGGSITI
//