ID A0A0N5BV44_STREA Unreviewed; 1317 AA.
AC A0A0N5BV44;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000971000.3};
RN [1] {ECO:0000313|WBParaSite:SPAL_0000971000.3}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR STRING; 174720.A0A0N5BV44; -.
DR WBParaSite; SPAL_0000971000.3; SPAL_0000971000.3; SPAL_0000971000.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17100; FERM_F1_PTPN3_like; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd14541; PTPc-N3_4; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF4; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}.
FT DOMAIN 31..318
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 908..980
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1042..1300
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1217..1291
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 668..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1317 AA; 149502 MW; 98940B75EDD04624 CRC64;
MRFGTGSYNV RHSEGLNPDT LRNTSNTKQT LSCTVYFLDD TERSFTIGKG SIGQEILDKV
FEHLELVERD FFGLQFLSFL DSQAEHPRMR WLDPQKSIKK QMVCPPFHLY FRVKFYVSDP
SKLAEEYTRY HFFLQVKRDL LEGRLLCPES SAALLASYAI QSEMGDYNIN DNEYIDNFKI
IPNQPCDLSK QIKELYKLHS GQTPAIAEYN FLDHAKRLDM YGVDLYEAHI EEGIQILVGV
NSYGICLFQN GQKINAYPWC SIMKLTFKKK VFNVVIRILN ELNEEEDKAF FFHIITSQSC
KLLWKSCIEH HTFFRLIAPP IPPPKSIFSL GSRYRYSGRT EFQTMEEMKR RARVERAFLR
ANSRNNFGRA TITGVGVRNC PSTCQQNSLE QANERDFNSF EATFDDADGG EYNLKGNNSI
YSFEKYDNDY IENSKNMNSI TSYTSWVAKM FPSTQWKKKQ CQLRKNFTLN KSLRINNNDS
STSNSSITSF FNKLFPKLES NRNNIAGRDD YVGNDCLKML NHRKVDEFDG LNYKQSGKSE
SVAPSPSNTL NRKVPNIKTH YSPVKIQEIE NNSNMAATKQ QLYDDKKISL RQNINQQYNK
NALDDRLRRV SQGRETTFSA SGNDEDGIRY CSGNWTVPQH NENYDSGFSN SSNGCGYYQQ
SINTGNDASL PSTLNNSITS SSSSRSPIHN SSINTKNCQN NSITTMHQNN NSTGNNYKKP
NVSSNSSSTA SSTSSAYGTA GSYSSNNSHH NNIMYTNPSN SSISNHTLTR SSNNTPRINN
SSTNPSNSSP YKNSPRIQQQ SGIVLNQMNG YSPRSSVASY SSYTSSNGLP STNNQSYGGS
GSNGSNNNHI SNGTLTSNKS ISKNLSSSSP VRQVSSLSQR RSPSSGIKPI NCSLANNYFS
NPEDNLVTIR MRPDIQGKFG FNVKGGSDQD HPVIVSKVAS GSSADKCYPR LNEGDQVIMI
NGEDVTHWTH DQVVRFIRSA KDTPTGELIL NIKPNVYRYG EHEEPTSFNV PEVKHVADNI
PKKDMLKQSL RILQENLRNG MCVEQFETLY RKNPEMTMFD SKSSCNVTKN RYRDILPYDE
TRVRLQKSVS GDYINASHVN IEIPSSGIIN RYIACQGPLP TTCGDFWQMV WEQSCSTIVM
LTTTIENDRV KCHQYWPRLH DSQDYGRLIV TCIKERETPH CAYREMSIKD IQTKEERRVS
QMQYTSWPDH GVPEDSKHFL DFVEEVRKTR HGSVNPMVVH CSAGIGRTGV LILMETAACK
IEANEPIYPI EIVRKMRDQR AMLIQTTEQY IFVCDSILKA YDHGILKPIS EFHKSPR
//
