ID A0A0N5BZA6_STREA Unreviewed; 768 AA.
AC A0A0N5BZA6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE SubName: Full=TOP4c domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001109900.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001109900.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001109900.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00011080}.
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DR AlphaFoldDB; A0A0N5BZA6; -.
DR STRING; 174720.A0A0N5BZA6; -.
DR WBParaSite; SPAL_0001109900.1; SPAL_0001109900.1; SPAL_0001109900.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR InterPro; IPR001154; TopoII_euk.
DR InterPro; IPR031660; TOPRIM_C.
DR PANTHER; PTHR10169:SF62; DNA TOPOISOMERASE 2 TOP-2-RELATED; 1.
DR PANTHER; PTHR10169; DNA TOPOISOMERASE/GYRASE; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR Pfam; PF16898; TOPRIM_C; 1.
DR PRINTS; PR01158; TOPISMRASEII.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 63..545
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 573..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 88578 MW; 0271C4629F666528 CRC64;
MDRHRIPFTY SGPECEEAVE MAFSKKKIEA RKVWLSNWMR EKKARRENGG IEEYLYNKDT
RSVSFVEFIN KELILFSNMD NERSIPCLVD GLKPGQRKVL FTCFRRADKK EVKVAQLAGA
VGEMSAYHHG EQSLMMTIIN LAQDYVGSNN INLLLPIGQF GTRLQGGKDS ASPRYIFTQL
NPVTKTLFVQ DDENVLRFLF EENQRIEPEW YCPIIPMILV NGAEGIGTAW STKIPNYNPR
DVMENIRRLI RGEEMKKMIP WYKHFEGTIT QVDEQKYISS GRVGLLDDES FEITELPVKT
WTQNYKESVL EELSNSTDKS PALIQDYKEY HTDQTVKFII KMTDQNMKKV LSQGIHEIFK
LQTPINTSSM VLFDAEGCLR KFESPEQICQ EFFVVRKKKY IERKEFLVGM LEAQSKRLSN
QARFIVAKIK GEIIMENRKK KNIVDQLIKE KFDPDPVKAW KDYIKKKELE MCGEVEIEEE
EESEDNETST DAGLKKRLAD YDYLVNMALI KLSEEEKDRL LKESGDKLAE LEELKKKTWA
DLWEHDLKVF EEALKKQEEK ELQDIEGAIK TAQSKLVKGG ASGKAKKNKV NVDVSSFKPN
PDAEIVKVEF EALKNKYEKK PKREKKQPIK VQGDEAASAL NNTDLKPPKA KKTKEPKEPK
EPKATKKSAS KKAKIEDDED SDAFDESESV MESPKIVQKR ARRNVAKTPF IEIDSDSEIE
MVTPVEEDNK KSAKRKSITP QKGKKTKRAK IESDDDESFN EFESDTSY
//
