ID   A0A0N5C329_STREA        Unreviewed;       972 AA.
AC   A0A0N5C329;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Nuclear receptor domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001238400.4};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001238400.4};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001238400.4}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|ARBA:ARBA00005993}.
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DR   AlphaFoldDB; A0A0N5C329; -.
DR   STRING; 174720.A0A0N5C329; -.
DR   WBParaSite; SPAL_0001238400.4; SPAL_0001238400.4; SPAL_0001238400.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06960; NR_DBD_HNF4A; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR031751; DUF4735.
DR   InterPro; IPR049636; HNF4-like_DBD.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24083:SF181; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-35; 1.
DR   Pfam; PF15882; DUF4735; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          413..488
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          553..822
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
SQ   SEQUENCE   972 AA;  112745 MW;  8067A55B4741D264 CRC64;
     MGIVAPSITF FTWHHARLVA LILNAFSGIL FYTENQVQQK NKLEKNEIFM LHLIDKQLDI
     YQKYYYGNGF HDDIFNGMKE ISEKARHILK SNHNDFLTFL NSKDFTIQLE EYKLTDERLR
     WDLKDLPNAN RREIINGRGF TFWFDNSCFQ ELLGNISSTC FKEYSNYKGL IEFDLTSRVQ
     YLLYGRKFAE NYFNHHLKIG YNSIVNEICA NMQDEFSKHK QNHYKNLIKL GKVQRDLLMN
     QVFACGQFGF LEISDLHILT SILSWQHPSL GCFSREIPDN LPNYGIARPD LKSQQSSPSN
     LCDSDSNFLG VYALMVYFRL LLEPPFKFRE YNLPEQPVYM GHISAEDKFK QFKYKDWVRD
     AGFPKELRIP KPEPIYCDNV IIPDENSGPS NKYEEEVSNA VNNTSIEETI EGSQICLICG
     DTAAGKHYGV VACNGCKGFF RRTVRRQYTY SCRYQGRCDV NKANRANCRY CRFKKCKDHG
     MRVDAVQAER DLIGKRKKSQ EILNSFDSIY NTPVKHMKMD NDSSGRTPFN NIQYSSSNIY
     NLQYPELPYR YSNPLDVIRY MIESEDMASA KLDWSSGKDI LKDLCKCENI MQHQKNSGIK
     KSNCYYNTKE YQQLVKEDGK VISRLEVLET LREMFQLTIH WSKSLQPFNK LSDDDKAILV
     KNFACQHFML CLGYRSMFNE EYLNIINDCI IEESIDYKQR NYCTNFLEKT MKELVEEMKR
     LQMDDVEFVA IKAASLFNNT CEGISKDGSN HVLEIKRSIL KALTDYINNK ITSESTRLCD
     LLISIVTTSK VLGGVLLENF IFKKILGISQ IDNLIQQFIL TNDTANDEDV SEMGNIDKVQ
     LSNVVQNDFS TMSPTNDTQP LALYKIINQN SNQVDHQHCQ KQQGIPGYPF TGAFDSIMTP
     QMPMKDINNS YFNGLKTNDY INHIQGYQEM EGIKNQHISS HTFVNTQLLN SWSVTNVQDH
     FLNGPSDCGR YQ
//