ID   A0A0N5C335_STREA        Unreviewed;       999 AA.
AC   A0A0N5C335;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001239000.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001239000.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362035}.
CC   -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC       {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0N5C335; -.
DR   STRING; 174720.A0A0N5C335; -.
DR   WBParaSite; SPAL_0001239000.1; SPAL_0001239000.1; SPAL_0001239000.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR   Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR   InterPro; IPR013769; Band3_cytoplasmic_dom.
DR   InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR   InterPro; IPR003020; HCO3_transpt_euk.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   NCBIfam; TIGR00834; ae; 1.
DR   PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR   PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR   Pfam; PF07565; Band_3_cyto; 1.
DR   Pfam; PF00955; HCO3_cotransp; 1.
DR   PRINTS; PR01231; HCO3TRNSPORT.
DR   SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362035};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362035};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT   TRANSMEM        445..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        472..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        526..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        558..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        638..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        676..694
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        726..743
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        764..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        847..868
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        895..914
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   TRANSMEM        920..941
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362035"
FT   DOMAIN          110..352
FT                   /note="Band 3 cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF07565"
FT   DOMAIN          409..900
FT                   /note="Bicarbonate transporter-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
SQ   SEQUENCE   999 AA;  113718 MW;  15C468D15D638A30 CRC64;
     MSRSRLSSSD GEKNKKELKV NKKISIIETY NNHEKYDLLK NVFLKSQNVF VGNQDDSFKG
     SLKNLIENVK IPTPAIMSEL LLYKEILYDS GDFETLWYES CRHIKYCQVV EGEGTRLSKP
     FITLMNIQSL FQIRNCFKKG VILLDLTVSS YKDLIDNVTS VCRQRNIIDD EECTLLRSIF
     SAPKYHFVNN KLRYIDRDSR YSGNKEAKFI DSSDDDGSIK EELDERVSLK DDKEEDDRFM
     SKLQPNTESS IIMCGVVRRL THPVCIFVRL KTKTQFYPEI PSHPVPTRFV FILLTPNENY
     KHELLYIGRT LCALLADDIF KNVVYNCTTN LIICEAIDEF ISQIISIPPK QLNIYNTRLD
     PIEDKSIEGR KIGIGLNEED DNDEVFEDYE NNMDNIDMSL DYQLIRTGKI FGGLVKDIKR
     KSPNFFSDFS DFFYGRFGQS LASTFFIFFA ALTSALTFGA VMEIALNKEM AAIENILACA
     ICGVIFGLFS GQPLNILTAT GPTLAFETII FSFSKTHNWD FLPFRFWVGL SIAIYLTIFI
     AFDLCTLVSL ITRYTEEAFT ILIGIVFILQ ALKDLISIGH SYPIQKNIHQ IFESPCLCNL
     TGTTLIHKLK KVKNFDPSSC LAIGGQPHGL MCDYKPDIFL FSIILTSITV FIAYLLTALR
     HSNFFSSKIR QSLSDFNIVI AITVSTILSI VVGLDVPTLK IPETFKPTKD RSWIINPLIF
     DTYETYLYAG LLGICYSILI MLDQQITSAI VNKKDHLLRK GNGYHLDLII VALLIVICAT
     FGLPFYIANT VISLMHVESL KIYTTCNAPG EKAQLLGIKE QRLTSIIPHI IIGFSVSLTA
     IIKLVPLPVL IGVFLYMGII SLSSLQFVQR LRLFFIPIKH QPDLPWLRNM PMYRVHLFTV
     TQIVCLTGLF LVKYNKTTSM IFPLMIVLII IIRLTILKVL FKERELLSLD GNPPKLKEIL
     KPKTALDIVE ERMKYSMIKK SGSKDSLKLS NSNTNLNLL
//