ID A0A0N5C4E8_STREA Unreviewed; 1420 AA.
AC A0A0N5C4E8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000313|WBParaSite:SPAL_0001282900.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001282900.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001282900.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 174720.A0A0N5C4E8; -.
DR WBParaSite; SPAL_0001282900.1; SPAL_0001282900.1; SPAL_0001282900.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 36..83
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 395..495
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 525..643
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 644..715
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 882..970
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 995..1222
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 295..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 160885 MW; 0470E46C8F14A810 CRC64;
MYRFTPDFKN ALIKNPKERC KNDIDIIFSH LKQLEGFKWI NDTALRKISR AARYEAYPMN
HILFRKGQPA TCWYILLTGS VYIDEQIQLP LGCFGKRNEV HLRRISDCII LQPSELIVID
YPDDQRVPIY QTIQETTNNI YTLNNSFQTN LKIKGTQFND QLDTPYFDCS QVQSSTLRPK
QKPLYEMTGE KGSNYNGIDN VDCSIVPQPT IGISRITVQP SSQTNRSVVH NNQISTIYKN
ISDVSTPLPI SGVAPNLPLK KDTTFKEPPI LPYHQILKNQ PPPYVRYRTH HNQLQRKSLD
ETAMSKSSDK STIGSSIKQP TLITVGGSSS SSRNDELSGL PEAFVDSDDE EGSCPSHDSF
QELRDNVREC LEKEPSMRTL DDILILLDFM SQMQAFASLP MSIRRQICLK MLFAVVQDAG
TVILQNGDKL DSWSVVVNGY VEWTKPNGEK VEYRMGDSFG ATASSAVQYH EGEMRTMTNN
CEFLLVEHKD FYHIMSTISQ HIEKVSDVTG EVVSETERRV TGNQVGLVII KAKPEKLLQL
LVEESDTISD EHYTEDYLLM YRVFVSDATE IFLRLKKWFK EPMFKEKIPR IVLLWVNSHF
NDFESNSKMI KLLEEFGDTL EQENLHSQLA LLNIACSVKS KTRTVTITRS NRDQELSFSL
IGGKEMNHKL FVADISNNCD PETIGLRRGD EILEVNGHSF SSITLSKALV LLKDSTHLSI
KVKWNLMGFK EMLFDMESKK NSYDYESISC GDNPYSSIRY GKNDSSGAYL PPRHHNSSSS
SVNTKSSNVS SKNSMMSKLI NIIKGSSSGS DSGFSNDLSN TSTIMNTSVV NNSSLPPLSG
TIRASRSNPD IHINIHRPIS TYKYSLALDP FDNVKSSNLN QNEEVIKVYR SDQTFKYLII
YPETTVGEIV KFALQEFGMN TETGHLEWSL CMTSVTPEGA IKQRTLPQTM TNMAKYLNLN
SRYYLKNNDR SEPLLPDDVA PDVLKESQTF LVDLNAHTIA VHLTLQDFAI FSKIEATEYV
DCLFEIKSAY GWPMLKKFED IFNVEMWWVA TEICSEKIVY KRAKLIKKFI KVARHCRELR
NFNSMFAILS GLEKPAVRRL QNSWERVPNK YVKMLNDMQT LLDPSRNMSK YRQHLLNVSQ
DPPVIPIYPV FKKDLIYSNE ANETYCEKLI NFEKLRIIGK IIRGVTKLSL VPYTQEVIQY
RDSLNMDSKG NTSTIKKLSG VKNGSQSRKK MYEQDLMIKK VKAYLEVMKI CDNENELDKM
SSECEPPQNS SSGNASSGTS RKRAPSPSSS SVSSHSNQSE QFARFHTPKF GVESPQAVQK
MLSLVQNSKI KPASNVKGYS PMQSPMLNNN RSTPKRSNAG IGRIPSFSSR SSSNSTDLHP
VDLTAESSSV TTFYTNANTT QNANSTEIGP GAFVRPVRRK
//
