ID A0A0N5C7M3_STREA Unreviewed; 616 AA.
AC A0A0N5C7M3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Neur_chan_memb domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001393500.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001393500.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001393500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR AlphaFoldDB; A0A0N5C7M3; -.
DR STRING; 174720.A0A0N5C7M3; -.
DR WBParaSite; SPAL_0001393500.1; SPAL_0001393500.1; SPAL_0001393500.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18990; LGIC_ECD_GABAAR; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF939; HISTAMINE-GATED CHLORIDE CHANNEL SUBUNIT 1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 372..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 135..341
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 351..603
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 616 AA; 71092 MW; FDF3C73F0507AE58 CRC64;
MIISYLARLV LILPEISSED ANRLKMIADK HIEMTGNKDI DLNYFGNKNN DFNSLAMTNL
PDKSFTNYGI HHTNKYEMKF KNINNQKNIQ ISKNPPWTQV VESNSIQEKI NDLNENIIKS
KFSDPCIPMN ETLRKDLIKK LFDESYDKNT LPSTNSTPVI VELTVQSITE ISEFSSSFSG
DIWFSQIWKD IRLEYGSNNY CLTNLSLSAH NLQHLWTPNV CFINTKRVEI HASPSQNVLL
LLFPNGTLWL NYRVSLTGVC RIDLKYFPFD FQECSLIFES YSYNTAEVRI VWREWDPVTI
PDPNAKKLPD FELVSFNHKK DTLVYTAGLW DQLEVIFVFK RLYGYYVLQA YLPTYLSVFI
SWIAFWIDTK ALPARITLGV SSLMALTFQF GNIMKNLPRV SYVKALDIWM FGCVGFIFLS
LVELAVVGFA DKLEAKKRRT RKARQMLLTR SDSEQQWLAR FNNHPIHVNL PSSHNITLQS
PCMNTNDIYS GSSPSDDYFQ ENNNYQNQSA GESPNITLRS NNFPQRNTTH ITSDCRENIN
KSPCCTQNCA WDVLTRSSKN GSQKKQHITV VQKKTRKISG EQIDAISAKL FPLLFTAFNI
FYWFYYIGMS TGVTHM
//
