ID   A0A0N5C9S5_STREA        Unreviewed;      1124 AA.
AC   A0A0N5C9S5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Degenerin-like protein unc-105 {ECO:0000313|WBParaSite:SPAL_0001465400.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001465400.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001465400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A0N5C9S5; -.
DR   STRING; 174720.A0A0N5C9S5; -.
DR   WBParaSite; SPAL_0001465400.1; SPAL_0001465400.1; SPAL_0001465400.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 2.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        179..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          985..1124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        992..1026
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1034..1048
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1068..1124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1124 AA;  126945 MW;  DB5A7CDFDBE9CCCE CRC64;
     MSNTNNNISG LTNYTSHPSS SDTPVSTIKQ RQPRGRTNSV HTQLSKKTSG TSNNSPKTSL
     SRSTLKYDAR TTPKRSMSKI SPNTLTVNND SNYGKPLSRR SFRNIGSFKE KYHGFASNGL
     HRLRRISRAD ISRLADHRGL PLRFRGQFDY RLIVSRFEKQ STFHGICHAA TAPNYKWRIM
     WYSAFSICFL ALIIQVFYLI RRYRMYEKTV DLDLKFESAP FPAVTICNLN PYKASAIQND
     PITKSTIDAF TSLMNKGAST IPGIANELAA AKSESLSRKK REETNSESRR YLQILAQCYC
     EVSTLSGVRK KGSCFAAYKG NISLTFTGNN LHNFHPSKCL CQLDRVSKTL WPCFPQNSWE
     KRMCSKCVKS LGHCPMKYIN KKLRSKRRKY YKDILQSLSK QNQTIRKNNI LKEIQNNSKN
     HKNSSKVECR CHEEYNHCVM NPENGYIPYI VPNDSLDDVL ERDYLSPQYA LSTTTTTTTT
     QAPSVVQALG LEELEDEIAI TTQAQQNLMF AVGAKPMDEK IAMSQTMSEL ILKCSFNQRD
     CDFKKDFKLH YDATYGNCYT FNWDRSKNVS ANRAGANYGL RLLLFANISE YLPTTESVGF
     RITVHDKFIT PFPDAFGYSA PTGFMTSFGV RMKQFIRLPS PYGRCLDYSE ADENFHIYRG
     YNYSVESCHR SCTQREVIKA CGCSDPMYPA FNNSEVCSVL DPVARGCIQN VTSKLTRDIS
     EGRYKDCICH QPCLESGYEV SFSAARWPSG TSKIMECEAS NDLCMEKYKK NAAMIQIFYE
     ELNFETLTES PAYSLTSALA DLGGLTGLWI GASVVSLLEI VALIIYTTQA YVQKKKLESA
     PPPPKISSNR SLANISKKSV KVLNSERSSK QSVLQEVDET KTEETMSEIQ KSSTYYIPPG
     ADLPCICSYN AYGHIEVMKV LCPQHGYLLR ARGIYEDDFY ADEWDEREES EEDEEEIVEG
     EEIYSQMEVE EGESINNMEI VDEDDEHTHS NPVTKNLLSK KPGDNKNQSI LQPIDSVNNN
     DNRKLLSPID DASILNNDDK EKSPPKETFK YVLPKFSKIK SLHNPIKGDG KNSKNSSEVS
     KGSKHSISPT SSTRDISSIA TIETSENSKS TSTSNGLTNL FKDK
//