ID   A0A0N5CC72_STREA        Unreviewed;       433 AA.
AC   A0A0N5CC72;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Chimerin 1 {ECO:0000313|WBParaSite:SPAL_0001548100.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001548100.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001548100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A0N5CC72; -.
DR   STRING; 174720.A0A0N5CC72; -.
DR   WBParaSite; SPAL_0001548100.1; SPAL_0001548100.1; SPAL_0001548100.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd20806; C1_CHN; 1.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR46075:SF2; RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          58..127
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          183..233
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          246..431
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   433 AA;  49854 MW;  FD01AE0BDD56630B CRC64;
     MSEFYPRSVI SNEFGDDSIS VDGYWKHNLL VLQEKAPKPI CVPCRKFIAN RPEQYGHEYH
     GLIERKEAEK LLRESGEGSY LVRASKRSAN ANTLCIFFDN QVLHYMLYYD GNHYLGEKRF
     ESLELMVADG LISMFLEKNA SEYIRKMAEE AVYEHSPYLI YQRAANNISS DGPVVVDDFT
     NRPHNFSSFT FKMPHYCDYC RNFMWGLVQQ GVKCNDCGFA AHKKCSERAY HDCRPEAKYV
     KRMFAVDLTT LCLAHNVSIA PVFKQCIDEV ERRGLHIEGI YRVSASHEQM DRLRKQYDTN
     PNSVNLSEVD DIHTVAGLLK LYLRLLPQQL VPFSNFQMLC DAYGMSQNPS ERALHIKKAL
     KKLEKWNCYT LDALLNHLRK VAEYSDKNKM NVANIATIFA PTVFCAGTIP SLPQHQHLLL
     DFLIKTPGIV PYV
//