ID   A0A0N5CCZ6_STREA        Unreviewed;       794 AA.
AC   A0A0N5CCZ6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   13-SEP-2023, entry version 35.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001574400.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001574400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   AlphaFoldDB; A0A0N5CCZ6; -.
DR   STRING; 174720.A0A0N5CCZ6; -.
DR   WBParaSite; SPAL_0001574400.1; SPAL_0001574400.1; SPAL_0001574400.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20338; BRcat_RBR_RNF19; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR11685:SF427; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        337..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          105..327
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          109..157
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          57..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..739
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   794 AA;  87582 MW;  CDA98A4D5E8A44B7 CRC64;
     MTANCISNLD TLIEDHEITA ENEATVSTAL LEDNNKSVST KKSSIPLLDM IITGSGHHNK
     KSYSKINKST HSDNDSVNNK SSFDKLTLKD GLSSSSKTLS SNVNTIKDCP LCMDEYPEDN
     IVTIACCNHK ACLDCIKAYL RIEIMESRVN ISCPECSEMI HPNEIYSLLK NFPELLEKYE
     NFSLRRVLAL DPDTRWCPAP DCDYAVIAQS CAACPQLKCG RIECSTLFCY HCKNIWHESQ
     TCDEARRKRM AKDSTTKKGY KRSTPGDKLN KGDVKACPRC KTLIVKMNDG SCNHMNCAVC
     NTEFCWLCLK EISDLHYLSL SGCSFWGKKP WNRKKKLLWQ IGTLIGAPVG IGLIACMAIP
     GIIGGFPFMV GRKVYQKLSS KSKLQRRFLT SLSVVGGVIA SPVLAVMAVG VGVPVLLAYV
     YGVVPLSICR NGDCGGGRNV DEDDELSMAS DNIMDLFDDD FESMSKSFDR TNIIEKIPTE
     GNKRMSMNSE LSKLINNKEQ GSIKSTLAIK NGRNGVGVDI YNGSRRRVSA DSYMIIGEEK
     TNYDDASVMG MAGSKYHFDD KSVNTVYTIN SGAQLENLNN SGDCNSNNAL SGFILDNKSL
     SESANGDNKN NLSSGGIFSI GGTELKLQNG GDSSSISSFK PYKIMFAGGK TIDMSNYNEP
     YPYQAKVFST DTATLFSKEH STTSTSSKSP HPNDDPYHIY SVLDRFKSVV SDDVCSDEQY
     HPSRSTNTKS QKYKYSSSNQ SIEVNTSMEV NNRTPTDTIL NIDESGTTHK VSKKNSRSIW
     NRIFKSKTKT GSDV
//