ID A0A0N5CD64_STREA Unreviewed; 1038 AA.
AC A0A0N5CD64;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=DH domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001581000.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001581000.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001581000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR AlphaFoldDB; A0A0N5CD64; -.
DR STRING; 174720.A0A0N5CD64; -.
DR WBParaSite; SPAL_0001581000.1; SPAL_0001581000.1; SPAL_0001581000.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 219..333
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 661..861
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 588..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 788..815
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1038 AA; 120224 MW; B55059AE0566F886 CRC64;
MAESNFHSPI FSKQLHLDYC NTYSTSSNSN PSITSMTYFN QHQVLPKGIT PSSPKLLWDT
KKANNNSKVK TGGTMFCEKG TKKDNTKRVV LTNSTIKQYS LQSVDKNYEN MLYEGVIMRS
DSKANKNKKI VRHSFDSELL TSDYLQNVIT NNEVNTINKA NKKLCNSIKN RKSYTLGLQK
LLDRNIINQN VMSKSFTNNK CLSGFRFNKM GNEFSGCGNQ EECFSSKAIL ENDKFFYKLS
NDREEWKKMF NDILTISSSE RYHVLETFFD ITGYDCNNEV VFTSYISSSS LVKKSSDRFI
IWNENNSVYG LNFLLSKDAE EFCAILSSRL IKEPLTNDCI TAQTSIIIES VEKENGDVIE
IIENKEVIFE QCFLTLQNNG LTLLIKIKGK QLMYAVDLLD CIILYDNVSA FIYLSHPSKV
FIFKCERPTL MYNFFVKAIH DSNILLTNEN EPSMIQNSLK IAHSKVGISD EINISKDDKL
FDKTESLLIN SSKHFLNFMF DMRIFVEEKK MLMDDKLLLS QVEQLAAMFV TKRHALAFSH
LYCAANKDIS IKKYFSYQNQ MYINIMKRSD GMWNLKNNNL LGECYKSSNN NNNENKMKSS
KSSDAIMTET TNPVTPQELS VSNLKKMLIP QNSNNSQKQY NDTGEKVANN LTKNDRKKRF
GESYVISELD EKKEEFLVRN VIELVESERV FVNDLNELKN ESVEILGPKL KMIIGELSNL
HRYFLNCLEE AKDDITINKN DDDYKFHCQA KNTIIRVCTL FINKSSRFKI YSDYSAAYTT
WIQKYLGNNQ LKEKIKQKKK ENLDKNQNIE SLLIKPIQRI LRYPLFLQKI VDSCNNETIE
YKQSKQALLR LQELASYINE MQRFREQFGM RLDDFANNNK KYLEEKGMNL DMKELLMFAH
IKLYTINIKE KISKKIDGVI LIFNTLVIIF IPEKKKDKNH KIIPINECIV INSFKHQLLK
DASNINLLEE DLENVFQIMH TNPYQKNQST FIIHCSCKEI KTQLLRNLNK AIKINTSGKG
CRPLSGSSQS DRGYESEK
//
