ID A0A0N5CG51_STREA Unreviewed; 5542 AA.
AC A0A0N5CG51;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001683000.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001683000.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001683000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR STRING; 174720.A0A0N5CG51; -.
DR WBParaSite; SPAL_0001683000.1; SPAL_0001683000.1; SPAL_0001683000.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00063; FN3; 9.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR31460; -; 1.
DR PANTHER; PTHR31460:SF3; MESOCENTIN; 1.
DR Pfam; PF00041; fn3; 9.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00092; VWA; 4.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00060; FN3; 11.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR SUPFAM; SSF53300; vWA-like; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS50234; VWFA; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 381..467
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 471..568
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 568..652
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 657..755
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 759..852
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 859..956
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 969..1061
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1073..1171
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1176..1283
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1285..1362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1369..1466
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1470..1574
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1581..1658
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1667..1779
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1784..1887
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1891..1985
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2087..2181
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2906..3088
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 3118..3229
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 4590..4765
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 4807..4986
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1457..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2228..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2356..2379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2404..2448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2478..2521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2558..2653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2744..2773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3371..3399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3420..3461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3738..3776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3967..3996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4104..4124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4176..4211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4316..4344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4395..4414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2228..2245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2247..2323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2490..2509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2561..2583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2595..2609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2629..2643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4179..4211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5542 AA; 612991 MW; F8D62378FFAAFE8D CRC64;
MVSLDKGRPQ FAFPEFGNTL LLIFNFPIFK TLNSFFKINS KFISIILLTL CFVSPILCKD
LDFAEPIILA HEGIGEPPTV KDHDIDIWES GVLIHQHNET NPLGSSNINM QQLIHEIRRV
KRDEPEVVDI ADIRKSFKNS TKSGAGRCVV SADLSSHYCG SVEVSTPPII PENAGKCIVS
QKSGREICYP SYTELDTSCT DYNEYPGSVV QPINIPHATV RVLAYFPLTN LQRLIKQYYR
QQGKQMPKNL QLGSPTYSKK DSFLYAKYEC NEGYEMIDEV DVMFCYNRQW VRTPPVCRGL
GACAENNGGC SHNCKAIGAN EVECSCSKGM VLDQTGKTCI IPVPEVFCRK LANCHCIPID
STQYSCDCPG RESCLLRKEA PKIYLEPSGP YEVKPGGSIN ITCYGVGFDY PKLSWHQVGE
ENTNIRPISG TIKTQQMLEI KNLYKTTDFI CSAENDMGVA SKQITITVMG PGYAPIIKKI
NPGRKSITLH WDKPVFTSNP ITTYTIYYTE KGKKPLKDWQ SIEVNEPNHS VTIPNLKPNT
KYHIKMRAND VLGPGKLGNS VAINTLKPAI KPEIKIAEGD TMFVKPLEPF VISCNVTRSD
PTPEIGWISK GRPVYKKEKF PGSVLHHDGL YEGTSFTCEA ENEAGKTQKT INVIVTGPLK
PEKVKGKVQG NNINVNWKPP LITNGAMKDY EILYTDDPSL PEDQWKKVSV GSPDANTFTL
ENLKEMTPYT IKMRGINDRG EGLVSDPIEL TTWLAPRPPK VSLTPAEDIE RKPSNDDLEH
VCKATGVPKP KIVWYWNDQP IEDGKDDFRI YDISPPDDDM ESQSKLISEV TTKSGQIKCQ
GVNNVGEDEA VNNVKILGPG SAPINISPTP NENGFDVTWE PPVLPNGKIT NYILYYTKNP
DDDLGDWKQM VVDGDLNKAT VVDQDEETNY YVKMQAVNED GPGLISEAFE VTTGQKHIPL
SVSLKLIDPE TYEDEGVPIV VDPNQPIKFK CFAEGRPTPT VTYSWLSTNN ETDSGSQPEP
VRIEPVADSP HTYVSVEIQT YTQTKRVLIC QARNPDGSQV SRQVVDVIKP GSPPQDIEVD
VANDNSAVIS WKDPRYPNGD LTAYKVYLSP DPSLPIDQWQ VIEVKDPIKN EKTFARGELE
PNTKYYVKIS AVNDNGEGIP SDTEQFETGS GAPLDAPYDI LTNVKEDNTL DVTWTGPKFP
NGPIEGYNIY FAPEDGVTDV DNYKEWAKIN VPSHDDHGSK TIDKGQYVFA PNTTYLLRIS
AINDLNEGPA SDPVKFETGT GETAPVITLN PPNNKVEVPP MGSVIVECTA TGVYKPVVQW
LDKDGNKVAD RLLQVSNIIK DDSYICIAEN NVGKVQEILQ ISVTGPGTPP NEIVGLPIGD
KVANIEWATP DLPNGAITGY VVEYAEIGPD GKTPTEWKTI NVTGPMEQIR LDNLKPKTDY
AVKVQAISSR GPGVISDPIR IKTLPTPPEK PETPEVTVHG NNTVEIRLPK VRDPENPSQF
INDYVIKYTK DHPPTDDAEW KELTYTAPDG PEDLVIPIYG ENVDPETKYH VKVIPRGEID
GPASDIVPFE TSDGIVPPTV PVLNVVTDKD GYVRLPPGSD YKVRCTSTGY PEPQILWVDE
LGNTLAEGEH YSIDDIKSSK KFRCIARNQG GEEETPLNIY IMGPGTAPED IKLSSFRPRT
IDVSFMPPEI TNGNITVYIV YYTPLDDQDP DKEIGQVPSK PVRDWQTYHV TGDNLNEGEQ
TAKITGVDPD TSYAVIVQAG NNDGPGPFSS TQTIRTISRA RESAPYDLKV VPFSPYSADV
EWKNPEPLEE EPIGYELFYV PADKKVESED DRLLDDWEKM TIDGFGTTTK IEDVLKPDTE
YVIKIRALFP DGPGVFSKAC ISRTLPLGNP PYITTSHGGH GVDGKTTVYL LPGSSYTVFC
NATGDPQPEV KWIRGGEHAI DPSTVKANKE HAEWSLRVYN VTTNAEFACV AQNSLGSAQW
TIDIEVLPQE DPEWQKKFVK PKLEDGQVKL EFTDELPEYL KNANEWIVLY SDDNSRPVEE
WDSITGTGPL KSISIPEMSE GKVYFVIVDN PERGIQTPTF SIMTPKPPSD IRVGTNINDE
TVVSFKPAIT SDVPIKEYEI KAVNKDDPSE IYFQTIPSDS DTNVIIDSIL PGTDYIFTIR
AKLENGEVLE SSPVEAKTSP AGIDCNCKDN QACQLISDTS GSVKTVCYCI EGYEMSRDGV
TCEAIGQSSS VRQDISVTQE PPTTESPIKI EHVEGKDDED TAVYPTVKED DKEKIDQSDV
KAHETDEGGP SIGEKSKEEE EQPKIPIERI EEYDDEEGTS TRPTDIYGKE VFEIIGPDGK
PLPTSSTGRY VNKLGEEIDL DSENRPLDPE GNLLPTKDTN QFVYPATDSQ NRILPTDTSG
IPVYPVVDGD GELYPTSPTT GARIDKTGKP IPTNEYGEPQ SETGQPLPIN EEGVHIYDVT
EPEEDVFATD SYGKIVYPIT APDGTPLQKN EEGRYVDSEG NEIPLNEEGK PVDADNQVLP
TTDKGVYIYP VTGEETVLPQ EPKSVDVIKG ETFTTVEAMG EEDISTERPK EDIIRKEDEM
KETPLVVGVT TESTDVVGKE DEEETKRYPD VVPPVITTKA PPPYEEKDVS VLTDSDEVSV
LPTDRDDVSA PPTDIFGKEI FEIVGPDGQT LPTSSTGRHI NKLGEEIDLD SENRPLDPEG
NVLPTDASGK YVYPATDSQN NILPTDVTGK AVYPIVTPDG ELYPTSSTGA RVDFTGKPIP
TNEYGEPQTE SGQKLPINDE GVHVYEVVEP EEQLHGTDSY GKIVYPITSP DGTPLQKNEE
GRYVDKDGNE IPLNEEGKPV DADNQVLPTT DKGVYIYPPV VADKILPTEP TKEGEVTQEI
LPPSDEGDEK FYGKDQQCAS LLRDSSLFFI FETSRASEPI FEKFRTILVD FFVNKLDIRQ
EKIGLANYGN AVEVLYDIGN YEDTEEIKET LMELHFTGGT ADPLLALKSV LDLIHETHEK
SEQVMILFTM TDITGAVKKK FDSLAEVEGL RVVIIHMDEF VKDTNPNHKL LQRVCTSLKQ
PVKQVTLFTP IYKDQTTTTP VPVYTTTVTV EEDKHERGEE VEITEPVKSC SLNHAKADIV
FAVADNVMDE SDYKNVIKSI SDVITKDLDM APDVTRVSVI NYGRSAAIPI SLGGYQEKGE
IAYTLKKTKQ SKELDKPDIN VLINAAHQQF STFSNRETSK IIVTFTNGED IHRYPYNMDR
LPYPLLVVTL DEFMEEVKEK KTKAKFLEEW NQLTNKVIVN FIESQCKSRF IDYPYAVSKI
KTLPTVQPTR PQETDREGQT LPYDEDKSAT ALPTDIYGKI IHPIVDIDGK PLPTSSSGRY
VNKLGEEIDL DSEDRPLDPL GRVLPKNPQD QYVYPPTDEN NNILPVDVYG RTVYPITDKD
GNLYPTSPTT KARVDHEGKP IPTSYKTGKP LSPEGQALPT DESGAFVYET PESEEAYTTN
VYGKPVYPIV DEDGNLLPKN EDGDFVDKDG NVIRTNDEGI PIGPDNQLLK KDDEGNYVFK
PEVDLEGITL PTDADGRPTY EIIGPDGQPL PTNVYGKKVY PIVDEDGNLL PKNRDGDFVD
KDGNVIKTND EGIPIGPDNQ LLKKDDEGNY VFKPEADLEG ITLPTDADGR PTYEIIGPDG
QPLPTSTTGK YVTKLGDEVP VDSYSRPLGP DGQVLPTDDE GKYVYPATDS DNNILPTDTS
GIPVYPIVDE DGQLYPTSRT TGQRVDESGK PIPTSAKTGV PVDESGTPLP TDSTGKYIYE
TKPSEGVIPT NVYGKKVYPI VDEDGNLLPK NREGNFVDKE GNVIKTTDDG IPIGPDNQLL
QKDNRGNYVY KTEEDATHRA EAPHLAGKAL PTDIYGDKIY EIIGPDGQPL PTSTTGRYIN
KLGEEIPLDS KDRPLGPDGR VLPTKETDQY VYPATDSQNN ILPTDTSGIP VYPIVDSEGQ
LYPTARTTGE RVDKSGKPIP TSAGTGIPVS KTGQPLPTEE SGVYVYDQEE ATILPTDIYG
RTVYEIIGLD GQPLPTSTTG RYVNKLGEEI GLDSQDRPLD PEGNVLPTRD TNQFVYPATD
RDGKVLPTDT SGIPVYPIVN EDGQLYPTSR TTGARVDETG KPIPTVEITG VPVSESGQSL
PTDEPGVYVY ETPKSGEALP TNAYGKPVYP IVNKEGQLLP KNDDGEYVDE KGDPIKITDE
GIPLGHDDKP LKQDDKGNYI YVPVPVTTTD KPIIIVSPDG QPLQKDDQGN YINSNGEIIK
FNEDMQPLDP NDEVLPTDES SAYIYPYIDE SGQILPTDTS RKPIYRIVDV EGNPLTQAPD
GRYIDEESNP IPTSSTGIPL KKTGEPMSKD KFGNFIYDPS LTGDILPTDK TLQIVDHLGV
PLKKDETGTV FVDQKGTPIN TDDQGRPLAP DGSVLPTNAM GQYYIEEVKE DETTLVPTGI
PVVDKNYSIL SYDNTPLKKD PKTGQFFNPI GQLIPVNDNH EPLDPNGNVL KKNDDGMYVY
PAIGPNGEIL ELSQTGKPIF PVTDIHGEYM PTTSDKLYTD HDGNVIPTSE TGVPLGINGS
PLPIGDKGYH VMIGPVSRTS QHCYVNSYIN LLIIYDASND IKVLDYRLLK ELAKNFLVEH
FNLDVNRVRV GLLKYGENAE VTLSFGDYDS EAQLLLKLGE ARRLKGDNNL ANALTQAIGE
FVIEQNENVP HVAIIFKNGK SATDITTPAK QLRENTRTNI YVVSNNGDYE EDRKLVGEGN
ERRIVKVNGW KNTKPTDLGV IADDICRYSP RVVDDENIPW PTRKPSYTIA PIYYEQKKCD
KIDFALDFIV LLDASDNVDA VTYEKIKDGL GTLIDEYLDM APDVVRIGFI QYSDKVNVPV
SLGHYQDKEE ILQIFKDLEK ESGIPIALKG FDAARVQLSE HGRKDIPNVI LLITTGKNRG
NTIGAAYDLR ETYGSQIFAL AINPDDDQLS SLRRIVGKEY SHDRLLSIDD VDQFRTEGIE
KINKALCSSI VVKEETDGIH RSSTTKRSTD HVEDADVDAY VTKTPSIRTT RSLKPTPLCK
DGIIRPFFFS LVIDTTSRSE ENDFKNTIKS LINFFYDKFE ATPMMAVTNL ITVNSKGIQD
RKLGLDIESL SHELSLVTQE PNDFSSPQLG LGIDEATMEA AKNAISGTTK VMIVISSDGT
SMDDPLPPAE FATYDFLHNI VSISLRNPSS DLLTKISGNS PTRVIHLSEW ENVEKLFTSW
TSFAICEAIK TQDTTNGIPK TQEDKPSRIS VVGTSPNSLS VSWICCTNDK QKYVIKYSPD
VTIPLKNWLS TNATCKDGFG KKIEDLPTDN NYYVCVFTSD QSKREDLKYN LANCNFVHID
RDTMAPDDFE HTLDTSLPDK CKCTCNNEGE VTAPSPCDLQ LYEHTFSPIG TLPPNVKPDD
CPCRIQSHRG LCPSGYYYNK GQCYDVNECL QQNGGCSHGC VNTPGDFYCA CPHGMTRDPA
DPKKCISINS SFDRITEMLA QYLHANAQSA AKNGLMAPTG VIDKTKPIKY KTVIESHDKN
QKITFEWSQM PAMVKKALKW LL
//
