ID A0A0N5CJ87_THECL Unreviewed; 689 AA.
AC A0A0N5CJ87;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN ORFNames=TCLT_LOCUS83 {ECO:0000313|EMBL:VDM94910.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000008201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000008201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM94910.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; UYYF01000005; VDM94910.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5CJ87; -.
DR STRING; 103827.A0A0N5CJ87; -.
DR WBParaSite; TCLT_0000008201-mRNA-1; TCLT_0000008201-mRNA-1; TCLT_0000008201.
DR OMA; FDWKNRQ; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR CDD; cd14801; STAT_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 470..551
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 689 AA; 78143 MW; 56CFFAB413FBD28F CRC64;
MLCYGEIKTA LLDVTKECHS LWEENKEMQA RFVNDLTELH RIQLAVNQLE NDHREDKLTQ
ARASMSSMQQ RASQLYSALM EKRCSLTQKL NDGVHNIAVL QNQLISECLY DWKNRQKLQQ
VGVSFERRDQ LIDEIQAEFE LLAEQNWQLR TYACWQMDLL RRGPQMNGQM AQTHVTNLNS
VLDNLTKLLC MLVSQSFVVA VQPEPVLKTQ HKFFAEVRLL IGDKLGIKQH LVNTNVTVRI
IAEEEARLLS TAQLSEKDVK TVGSISNDFE KMTTDDKGHM SAKFSNSKLT RIAHRKPPPK
GGQGDAKVSV NLQTATDQKY ALLFHITPFQ LGNLGKFDVW TLSLPIMVTV HGSQDCDAQG
AVLWQRAFSD VNRTSLSSDI GAVSWRDLSQ VLRHKFAMIT GAERIVSDSD LSYMAEKLNI
SGDEEKQIIT LHRFAKQNLR DDVNFSFWEW FFAIMQLIKH KLLKFWNEGW LIGFISKQDA
SSQMVSAPHL TFLLRFSDTQ TGAVSIGFVC DDEDRKVPFH LSPFSIKDLD QLSLAQRIAS
CPQLKDIKYL YPDIDKDDML RYFESEERQK SLSPTGYIQS EIVMVAKTGG KTVCPVGGDS
PLSSLSAQTK LDWSPGETFA RTQSTEIIEN YNNEEVISIL SISSDNDIEA LLGPGFYPQF
PNQPLQLVDL SHVHDSSCVQ KNSSDSMEE
//
