ID A0A0N5CLU0_THECL Unreviewed; 1427 AA.
AC A0A0N5CLU0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=UDENN domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000109101-mRNA-1};
GN ORFNames=TCLT_LOCUS1092 {ECO:0000313|EMBL:VDM96342.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000109101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000109101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM96342.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; UYYF01000117; VDM96342.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CLU0; -.
DR WBParaSite; TCLT_0000109101-mRNA-1; TCLT_0000109101-mRNA-1; TCLT_0000109101.
DR OMA; KVTQEMY; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd17678; RUN2_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 39..592
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 764..1070
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1072..1182
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1279..1423
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 159..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1427 AA; 163081 MW; D95FED8238F3C21D CRC64;
MSNVSAEVAT VAEASTSDLT LVDYFVVVGH DTTTSLQMEV GSAVSFDASE LLYFPPLERS
YVASVLYHFP ERRNAYLFPT EIVSLCMPKG LRFYTQNDVP LPAVHTFANI REDGSRVNGC
ALIYHEEVKD IGLCEQMSQL HTEHVRFLTV REKAIERTHV PPGTISGGTH TLPRESRKNH
AKRTSYYDSG NSRLYMAKCI CLISRIPFVS AGERLLTALH SVFTSEIQPP QLPLESYIYW
ILNEVPLPAP GSTLKLCLDQ IDIVLQRPGP NELPFFDYAI GSLFNLLTVD KFLRLFTCFL
LEHQIILCSR KSLCALAFPF RWQLAYVPIL PLSQLKFMEA PVPFVMGLCY DDTLSEQVFQ
GNMCVLNVDS GELSMPEDVP SFPDRAEFAR EVASVLIRCE EQSIIVDGEI VKRRIGIKSR
DDWCRKRMSR SFDDETLVNM LEEDDFSRRT ISRKDLPPLP LDDVLRQSEV LARVTAIARR
AGVTVPFESI EKELQSNDSY TNSPDMKVNN AVREVFVNRF AWLFYSYEHF VINSVCQDLE
TYFASRESVA NFDKAAFLSD QPNCNLPFLA AFLETQMFTS FIDAKIVSQW ETPDENLQIF
DFRIQALRTK YGLQMVHTPT YEKAPLSFDS EEIIAKREEA LDYIVPLPHE LPGTSTRLYD
GTFPELNEAV LEGSVVRSPM PSPWKQRHRR LRPKLLENTV VSANTSSRQG SYKADTPKQI
AHQNWKFVEQ LLKETKGKTK RMLVEKMGKE ALQLGHSDAI VNGLEENTLV ASFCDLLERI
WAHGLIKKQG KSSLWAHILN HQEVEKLGIL CRSTTRRNSA LTPDIDEINS GTFKQQENIE
IVTSINNDSC PKLAKNVQQQ CIDDPHATIW SLPILRAANF ICNKLSSNVN NYMEYTNWKE
PFRTMNVSPN LGPLRHSRSS QKIFRKGAIL HKANSFDDLA PHWNIGEVNV NENLTDSPYK
KSSSRTNSPD LRQFLSPLPM HIAYDLKNVL RMTDIKTDIG YARAFVRLAL ERKLLYKHLK
TILSNSRLLQ QLYKRYAFLR CDDEKEQFLY HVLSLNAAEF NCFTNTFKNT KMLYHVLLVT
QNSRPTIPWP LWVIITGSLC STAAIEVKQG TNDFTFDYRN LGILSTLRVG HGDLNVSNGA
TPKWFLDYVL VRNEITGQSY RFCCGRWFGK GVDDDSLERL LVAERQPLAD HNEVSVDENC
SERIPKISLK NRTPAPRSRS PSTSRSENFS HRSSRVRLTE IQHQLGEAVN ALVKYFYTNS
EAHGHGELTQ LLCAPGKGFV SVMVSVFLCG RQDSIWSTRL FRPHYPWDYI EKVCIWFWDL
IHLDDAKKLT REQHSLIIQA CSLARRISSN TFLGKDGKFQ LFILIAVRDH ILSGLLPLMA
WTPITSQMYE EPCFLRTPHY LNYLSKLISS LNEFHFILEK SLVYGIE
//
