ID A0A0N5CMU0_THECL Unreviewed; 1205 AA.
AC A0A0N5CMU0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Doublecortin domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000147901-mRNA-1};
GN ORFNames=TCLT_LOCUS1480 {ECO:0000313|EMBL:VDM96949.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000147901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000147901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM96949.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; UYYF01000194; VDM96949.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CMU0; -.
DR WBParaSite; TCLT_0000147901-mRNA-1; TCLT_0000147901-mRNA-1; TCLT_0000147901.
DR OMA; WILSMTI; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 2.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 2.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF6; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF03607; DCX; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF01477; PLAT; 1.
DR SMART; SM00537; DCX; 2.
DR SMART; SM00015; IQ; 2.
DR SUPFAM; SSF89837; Doublecortin (DC); 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS50095; PLAT; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 65..147
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 608..726
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 746..861
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1158..1205
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1205 AA; 136339 MW; 2F9DD9A3AAB402F2 CRC64;
MSEAEYTATT LPWSSSRSTS DPQSTSQMLN HQPFKLSSNA PNLTNGGVRN FPASNRSFNH
PYSAKIVFFY KEGDIYFTGI RVPVSKARYR TIESLLDDLN SNISMPFGVR RLTTPRGKTV
IKNIDQLQHY GRYVASSFKT SRPLNLSMVE KFKKIRQINR TNGLQLNRRA WFNQKQKKNG
GSKLSPKLSD VPITAKQILF VLNGQPSRIY WVALDSLRSR TIESVLEEVS EGLQTTIFKL
HTFSGKRIIS INDIFSLNEA RLLAVPRNER PKICGSNISM HLPPLLPPTK ILPPSFNAQT
CIAKQTIHSS TRENSIEQSQ RSNSNSKTMP LTVMNRMNSI NKLQTLSPKS YREIRIESPQ
YCPGSLLCEK SVEKQGEMNI TNDEEKSKTV NERNESERMS GNQNLSAEGN DQSNQSSKNT
DLEMLMTEKV LLEKNSGTEL EANRRQLMNC TETDEQKIQH ICPSFSNRFE HNKNFDAEEV
SEVQKAATKI QAVYRGYSVR KKFKDEHKSH TELPKYSQQD DQFKLQTEAA IIIQASWRGH
HSRKLLKQQK LAQAMERQVT TTESDFGAVK LLESQTSNCG SNGCPVASDP SSNFDENDMS
STDDSENITY TVSVITGNRW AADTDLDLFI ILYGELNKSD KQFLRQDTNE PKFRQNRMDS
FHIKSAKLGL LQKIIIGHDH IGYGAGVYIE RILVTENIAD GRQYLFQCTK WLDSGQVDGK
IERILKTTAF CYLTPILYDD IKATSGRWEL ILHSGKPDGS GATTSNLNIV GYSNDSCSVT
SKIYDNRMAK VPSASLVQVD FGDIGNLLKI RIEIDGYGDM PDYYLDYVEL RDLDTEEHMV
SYVRKWMKIG SDDKNAQPFR EFPVFRAAFE PLNIFSYEGK IKLTSRKIPF LDGSIAYTKI
FGELGETGLI PINFQNASDS TLEVPFKAEA VSVGRIRNIR IYIKMSNIGD EIYEGMQVLQ
SIYHKRLGKR SIPVAGDWIT DKVTIRESHH APYRFVLSFN QQTEMEGLPT KMRKKKVSPK
KQQHWILSMT IGKESTLVPK VMICSQIDCV EMAIISTTPT DMIINFEKTT NIPIITKVRV
SVSGDRKLNH TSSNYKPASS HNMIEILKMK LHDSLNGDEV RFPAVNTILT SESVYEFPAV
WPDIPPSSSK FYFSIADVVY IITIKSGESN GHFDVHLTLI GSKGETGFRK LTNGDTDPFQ
AQKVC
//
