ID A0A0N5CN19_THECL Unreviewed; 1051 AA.
AC A0A0N5CN19;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000156101-mRNA-1};
GN ORFNames=TCLT_LOCUS1562 {ECO:0000313|EMBL:VDM97071.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000156101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000156101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM97071.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYF01000212; VDM97071.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CN19; -.
DR WBParaSite; TCLT_0000156101-mRNA-1; TCLT_0000156101-mRNA-1; TCLT_0000156101.
DR OMA; YDRCGEP; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003886; NIDO_dom.
DR PANTHER; PTHR13802; MUCIN 4-RELATED; 1.
DR PANTHER; PTHR13802:SF59; NIDOGEN; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF06119; NIDO; 2.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00539; NIDO; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51220; NIDO; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 89..228
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 339..379
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 457..599
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT REGION 620..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 116734 MW; A66CCCEC739AF42E CRC64;
MNKKRMKYLI ITAPLFSSRL FEYGLNAGDQ ELLKSLDVTK KIVLTYPLRF YGLDTSTIYI
SSNGGIGVEK NIRSYQAGVL PSDLKLIAVF WNRNDLRSGG HVYFREVTAG RVLERGQSEI
RYQYDEIAKV KTCLLVTWEK MQPLGATPLP DDNTNTFQVA LFITDNGTFV NFIYKNIGWT
QGAEAGFNKG DRKEYFALPT SGTGNIMYLE EYGNTGIPGE WMFKLGDAKV ERCKAGIKGD
TCDEECSAGE WGPDCALCCH CASGSCNAIN GDCVGGKCSS CWTGPPSCQQ KKDDCHALAT
EHCVPNAISF ADHDRCGEPI QRCQCLSGFK GDGYTKCDDI DECSLPNSCH QNAICNNTPG
RYFCTCAEGF IGDGINECTI SLLYSYHRHQ ELPKDKSGKL VLHLKQPLRI FGKQSEQLTV
SSFGIISIDD DDNDDDGSRE ITAIPRLASS GLHGIAPFYA NINHRRGDGR IFANETFDTE
VLSRATKTVV SNTDDKSFMA TSAVLVTFIN VTGIDQMSTG NSFQILLIGG TNKQRQNKTY
AQLLYKDLTW IDRAEAGILT YGSKNPLLLP GSGTDDIIHL TRDSNIAQPG QWLFRVDSDD
VQMCFHPNLV APYCEEYQDH QPHPTTLTSP KLEESEISDK EKSEVVDEAE NDELIEIPGP
QVIQPVLVDR LPSDAHLPSQ KNIIKSNQEI VKNLPNVTQK IATPHVPLIS LDRLDIEDLP
PDAFDITFPP FITVVPKLFT SSNVAGKSEI VTGVENEATL SESGISTSTE ISEDALSAVH
TSVGGITTEV FTKSSDSWLT STEVTKRIKQ VKPTKIDFDY DDRQTHIFVS DRSPTEEMPE
SAIDQQQKKI QPSQKSTEKA LPTEVTTLDY EENDLLQSIT TSKPLFIFTT ISKVINLQKR
PMPTKPKLIT AFGTSLATPH GPYDIRNDVK IEASSSSSLR AERHFRDMYF PNHQQIYPIG
TATYALRKDS KHFNGSYEDH LEKAARLSSE LSSYNQNGRV SLYGSYWNLT PGNASANSTN
GLSTSNRQSP YSQYSTQQVF IFLHNFYYNN N
//
