ID   A0A0N5CU49_THECL        Unreviewed;       704 AA.
AC   A0A0N5CU49;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Apple domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000376901-mRNA-1};
GN   ORFNames=TCLT_LOCUS3758 {ECO:0000313|EMBL:VDN00760.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000376901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000376901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN00760.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYF01004266; VDN00760.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5CU49; -.
DR   WBParaSite; TCLT_0000376901-mRNA-1; TCLT_0000376901-mRNA-1; TCLT_0000376901.
DR   OMA; LRMRYND; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01099; PAN_AP_HGF; 1.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR47327:SF17; CUTICLIN-LIKE; 1.
DR   PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR   Pfam; PF00024; PAN_1; 3.
DR   SMART; SM00473; PAN_AP; 3.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR   PROSITE; PS50948; PAN; 3.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        648..672
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..85
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          96..182
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          193..271
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          280..553
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
SQ   SEQUENCE   704 AA;  81643 MW;  CFF415896571AAFF CRC64;
     MNANCACITY LIEHGRVAEG KVVDKFITTN FQDCLQHCSK HKDCTAVNFL IDVQDESICL
     LIDQKINGIE SELPVPEIII YSATSFCITQ NLISHCNNNK IWSFERFPRK NLIDDQFVVN
     AERNISLQQC LHNCLKREQC RASLYNKEFA HCRYLNVSIQ NVHNIRKFFK HSKNVDLYEN
     NYFTENYLNL AQCHFIRMQS SGFTNVFDER IAHVEDKDQC ESLCLSWSSG NCRSFTYHQK
     TQLCYLSHSS SRTLNKNLAE NYDPNLFTGD LEDCIQFKLM CKPDRMHLYG MSVKMFSGIL
     STKNNKKVYC EKKFLNVYKF DAEILYDECG MKKSLSPHLT FSNLIMLKEG STELITVRDK
     ILKVVCHIHK DLEFIPENQY LSFQFQIDDE NTTKQMLFIY LIFKLFNNLK LVCFKFALTK
     NMRIASELKN YAMKPKYTLE VMDDNRKSIE QVRTGDKGFI LITLHEKPVT FSIIDMIARD
     VKTGTTLTMI DSNGCIVRDE LLTGIHWIDK NHLQLAIVFD GFSDDAEIIY EAYVKQCGEF
     CHLKSCEGLN VNSNQQAIHT NKLWKRHSLV TLSQSRVFQL SDDIYAVKSS HKLKLERKFQ
     ESIFENNDLS KEAIVLVPQA VIHNNGNRQK LSAIENQLTC DAEELKCLII FVLFCFQIFL
     LAVIVFIAFA ILQRCLQQRT HFSDGIQLMQ NTENSKDTLE QSSS
//